# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4707366 | B | Displacement of [3H]-methylspiperone from recombinant human D2 receptor stably expressed in CHO-K1 cell membranes measured after 60 mins by microbeta2 scintillation counting method | Homo sapiens | 21 | cell membrane format | Scientific Literature | ||
2. | ALA4707367 | B | Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor stably expressed in CHO-K1 cell membranes measured after 60 mins by microbeta2 scintillation counting method | Homo sapiens | 21 | cell membrane format | Scientific Literature | ||
3. | ALA4707368 | B | Displacement of [3H]-prazosin from alpha1 adrenergic receptor in rat cortex measured after 30 mins by microbeta2 scintillation counting method | Rattus norvegicus | 21 | tissue-based format | Scientific Literature | ||
4. | ALA4707398 | F | Bias factor, ratio of biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation levels to biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
5. | ALA4707446 | B | Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation levels incubated for 15 mins by Alphalisa assay relative to serotonin | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
6. | ALA4707447 | B | Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation levels incubated for 15 mins by Alphalisa assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
7. | ALA4707448 | F | Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay relative to serotonin | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
8. | ALA4707449 | F | Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
9. | ALA4707450 | B | Biased agonist activity at Gal4-VP16 transcription factor linked human 5-HT1A receptor expressed in human U2OS cells assessed as stimulation of beta-arrestin recruitment measured after 5 hrs by Tango assay relative to serotonin | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
10. | ALA4707451 | B | Biased agonist activity at Gal4-VP16 transcription factor linked human 5-HT1A receptor expressed in human U2OS cells assessed as stimulation of beta-arrestin recruitment measured after 5 hrs by Tango assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
11. | ALA4707452 | F | Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay relative to serotonin | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
12. | ALA4707453 | F | Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
13. | ALA4707454 | B | Bias factor, ratio of biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation levels to biased agonist activity at Gal4-VP16 transcription factor linked human 5-HT1A receptor expressed in human U2OS cells assessed as stimulation of beta-arrestin recruitment | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
14. | ALA4707456 | F | Bias factor, ratio of biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation to biased agonist activity at Gal4-VP16 transcription factor linked human 5-HT1A receptor expressed in human U2OS cells assessed as stimulation of beta-arrestin recruitment | Homo sapiens | 16 | cell-based format | Scientific Literature |