| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4731051 | B | Mechanism based inactivation of pig brain GABA-AT assessed as inactivation rate constant using GABA as substrate in presence of NADP+ and alpha-ketoglutarate by SSDH coupled enzyme based UV-Vis spectrophotometry | Sus scrofa | 5 | assay format | Scientific Literature | ||
| 2. | ALA4731052 | B | Binding affinity pig brain GABA-AT assessed as inactivation constant using GABA as substrate in presence of NADP+ and alpha-ketoglutarate by SSDH coupled enzyme based UV-Vis spectrophotometry | Sus scrofa | 7 | assay format | Scientific Literature | ||
| 3. | ALA4731053 | B | Mechanism based inactivation of pig brain GABA-AT assessed as ratio of Kinact to Ki using GABA as substrate in presence of NADP+ and alpha-ketoglutarate by SSDH coupled enzyme based UV-Vis spectrophotometry | Sus scrofa | 5 | assay format | Scientific Literature | ||
| 4. | ALA4731064 | B | Potency index, ratio of (1R,3S,4S)-3-amino-4-fluorocyclopentanecarboxylic acid Ki to test compound Ki for binding affinity to pig brain GABA-AT assessed as inhibition constant using GABA as substrate in presence of NADP+, alpha-ketoglutarate by SSDH coupled enzyme based UV-Vis spectrophotometry | Sus scrofa | 1 | assay format | Scientific Literature | ||
| 5. | ALA4731065 | A | Irreversible inhibition of pig brain GABA-AT assessed as regeneration of enzyme activity at 10 to 40 equiv measured after 4 days in presence of excess PLP and alpha-ketoglutarate by dialysis method | Sus scrofa | 1 | assay format | Scientific Literature | ||
| 6. | ALA4731066 | B | Inactivation of pig brain GABA-AT assessed as kinact/Ki ratio using GABA as substrate in presence of NADP+, alpha-ketoglutarate and SSDH by SSDH coupled enzyme based UV-Vis spectrophotometry relative to (1R,3S,4S)-3-amino-4-fluorocyclopentanecarboxylic acid | Sus scrofa | 1 | assay format | Scientific Literature | ||
| 7. | ALA4731067 | B | Inactivation of pig brain GABA-AT assessed as partition ratio by measuring number of molecules required for enzyme inactivation | Sus scrofa | 2 | assay format | Scientific Literature | ||
| 8. | ALA4731068 | B | Inhibition of aspartate aminotransferase (unknown origin) up to 10 mM by SSDH coupled enzyme based UV-Vis spectrophotometry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4731069 | B | Inhibition of alanine aminotransferase (unknown origin) up to 10 mM by SSDH coupled enzyme based UV-Vis spectrophotometry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4731070 | B | Inhibition of ornithine aminotransferase (unknown origin) assessed as inactivation constant by SSDH coupled enzyme based UV-Vis spectrophotometry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4731071 | B | Binding affinity to ornithine aminotransferase (unknown origin) assessed as inhibition constant by SSDH coupled enzyme based UV-Vis spectrophotometry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4731072 | B | Selectivity ratio of Ki for pig brain GABA-AT using GABA as substrate in presence of NADP+, alpha-ketoglutarate and SSDH by SSDH coupled enzyme based UV-Vis spectrophotometry to Ki for ornithine aminotransferase (unknown origin) by SSDH coupled enzyme based UV-Vis spectrophotometry | 1 | assay format | Scientific Literature | |||
| 13. | ALA4731073 | B | Substrate activity at pig brain GABA-AT assessed as formation of M6' by measuring molecular weight in presence of PLP by LC-MS/MS analysis | Sus scrofa | 1 | assay format | Scientific Literature | ||
| 14. | ALA4731074 | B | Substrate activity at pig brain GABA-AT assessed as halide ion elimination by measuring formation of M3' in presence of PLP by LC-MS/MS analysis | Sus scrofa | 1 | assay format | Scientific Literature | ||
| 15. | ALA4731075 | B | Inactivation of pig brain GABA-AT assessed as number of fluoride ions released per inactivation event in presence of varying levels of NaF and 10 uM fluoride ions by fluoride electrode based analytical method | Sus scrofa | 1 | assay format | Scientific Literature | ||
| 16. | ALA4731076 | B | Inactivation of pig brain GABA-AT assessed as percentage of compound underwent fluoride ion elimination assessed per inactivation event in presence of varying levels of NaF and 10 uM fluoride ions by fluoride electrode based analytical method | Sus scrofa | 1 | assay format | Scientific Literature | ||
| 17. | ALA4731077 | B | Substrate activity at pig brain GABA-AT assessed as formation of M7' by measuring molecular weight in presence of PLP by LC-MS/MS analysis | Sus scrofa | 1 | assay format | Scientific Literature | ||
| 18. | ALA4731078 | B | Binding affinity to pig brain GABA-AT assessed as adduct formation by measuring change in protein mass by LC-MS/MS analysis | Sus scrofa | 4 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!