# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4686847 | F | Anesthetic activity in Xenopus laevis tadpoles assessed as increase in loss of righting reflex incubated for 30 to 60 mins | Xenopus laevis | 5 | ALA4680248 | organism-based format | Scientific Literature | |
2. | ALA4686848 | A | Toxicity in Xenopus laevis tadpoles | Xenopus laevis | 1 | ALA4680248 | assay format | Scientific Literature | |
3. | ALA4686849 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10 mins by liquid scintillation counting method | Homo sapiens | 5 | ALA4680248 | cell membrane format | Scientific Literature | |
4. | ALA4686850 | B | Positive allosteric modulation of GABAA alpha1beta3 in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4680248 | cell membrane format | Scientific Literature | |
5. | ALA4686851 | B | Positive allosteric modulation of GABAA alpha1beta3 M286C mutant in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4680248 | cell membrane format | Scientific Literature | |
6. | ALA4686852 | B | Positive allosteric modulation of GABAA beta3alpha1 A291C mutant in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4680248 | cell membrane format | Scientific Literature | |
7. | ALA4686853 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]flunitrazepam binding measured after 10 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4680248 | cell membrane format | Scientific Literature | |
8. | ALA4686854 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]flunitrazepam binding measured after 10 mins by liquid scintillation counting method relative to control | Homo sapiens | 1 | ALA4680248 | cell membrane format | Scientific Literature | |
9. | ALA4686855 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10 mins by liquid scintillation counting method relative to control | Homo sapiens | 1 | ALA4680248 | cell membrane format | Scientific Literature | |
10. | ALA4686856 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current by two microelectrode voltage-clamp electrophysiology relative to control | Homo sapiens | 1 | ALA4680248 | cell-based format | Scientific Literature | |
11. | ALA4686857 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current by two microelectrode voltage-clamp electrophysiology | Homo sapiens | 1 | ALA4680248 | cell-based format | Scientific Literature | |
12. | ALA4686858 | B | Agonist activity at GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes up to 100 uM by two microelectrode voltage-clamp electrophysiology | Homo sapiens | 1 | ALA4680248 | cell-based format | Scientific Literature | |
13. | ALA4686859 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current at 4 uM by two microelectrode voltage-clamp electrophysiology relative to GABA EC50 | Homo sapiens | 1 | ALA4680248 | cell-based format | Scientific Literature | |
14. | ALA4686860 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in 1 mM GABA-induced current at 4 uM by two microelectrode voltage-clamp electrophysiology relative to control | Homo sapiens | 1 | ALA4680248 | cell-based format | Scientific Literature | |
15. | ALA4686861 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L N265M mutant (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current at 5 uM by two microelectrode voltage-clamp electrophysiology | Homo sapiens | 2 | ALA4680248 | cell-based format | Scientific Literature | |
16. | ALA4686865 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L S270I mutant (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current at 5 uM by two microelectrode voltage-clamp electrophysiology | Homo sapiens | 2 | ALA4680248 | cell-based format | Scientific Literature | |
17. | ALA4686866 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L S280W mutant (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current at 5 uM by two microelectrode voltage-clamp electrophysiology | Homo sapiens | 2 | ALA4680248 | cell-based format | Scientific Literature | |
18. | ALA4686867 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L M227W mutant (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current at 5 uM by two microelectrode voltage-clamp electrophysiology | Homo sapiens | 2 | ALA4680248 | cell-based format | Scientific Literature | |
19. | ALA4686869 | B | Positive allosteric modulation of GABAA alpha1beta3gamma2L I242W mutant (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current at 5 uM by two microelectrode voltage-clamp electrophysiology | Homo sapiens | 2 | ALA4680248 | cell-based format | Scientific Literature | |
20. | ALA4686871 | B | Inhibition of [3H]azietomidate labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in photoincorporation at M236 residues of alpha1 subunit measured after 30 mins in presence of GABA by liquid scintillation counting method | Homo sapiens | 5 | ALA4680248 | cell-based format | Scientific Literature |