# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4686879 | A | Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
2. | ALA4686880 | B | Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
3. | ALA4686881 | A | Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay relative to GW3965 | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
4. | ALA4686882 | B | Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay relative to GW3965 | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
5. | ALA4686883 | U | Selectivity index, ratio of EC50 for agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells to EC50 for agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
6. | ALA4686884 | B | Displacement of hyodeoxycholicacid-based fluorescent tracer from recombinant human LXRbeta LBD (215 to 461 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 10 mins under shaking condition and measured after 30 mins by fluorescence polarization assay | Homo sapiens | 24 | assay format | Scientific Literature | ||
7. | ALA4686885 | F | Antiproliferative activity against human U87 cells overexpressing EGFR variant III measured after 7 days by CCK8 assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
8. | ALA5141020 | F | Cytotoxicity against human U-251 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA5141055 | F | Cytotoxicity against U87MG Human EGFR vIII cells | Homo sapiens | 1 | cell-based format | Scientific Literature |