# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4719941 | F | Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction in DCG IV-induced inhibition of forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by incubation with cAMP-d2 conjugate and anti-cAMP cryptate for 1 hr by HTRF assay | Homo sapiens | 18 | ALA4715808 | cell-based format | Scientific Literature | |
2. | ALA4719942 | F | Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction in DCG IV-induced inhibition of forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by incubation with cAMP-d2 conjugate and anti-cAMP cryptate for 1 hr by HTRF assay | Homo sapiens | 18 | ALA4715808 | cell-based format | Scientific Literature | |
3. | ALA4719945 | F | Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction in DCG IV-induced inhibition of forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by incubation with cAMP-d2 conjugate and anti-cAMP cryptate for 1 hr by HTRF assay relative to glutamate | Homo sapiens | 16 | ALA4715808 | cell-based format | Scientific Literature | |
4. | ALA4719946 | F | Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction in DCG IV-induced inhibition of forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by incubation with cAMP-d2 conjugate and anti-cAMP cryptate for 1 hr by HTRF assay relative to glutamate | Homo sapiens | 16 | ALA4715808 | cell-based format | Scientific Literature | |
5. | ALA4719947 | B | Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90 mins by top count scintillation method | Homo sapiens | 17 | ALA4715808 | cell membrane format | Scientific Literature | |
6. | ALA4719948 | B | Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90 mins by top count scintillation method | Homo sapiens | 17 | ALA4715808 | cell membrane format | Scientific Literature | |
7. | ALA4719949 | B | Selectivity ratio of EC50 for antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 to Ki for displacement of [3H]-LY459477 from human recombinant mGlu3 stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 | Homo sapiens | 4 | ALA4715808 | cell-based format | Scientific Literature |