# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4677392 | B | Binding affinity to signal peptide of human CD4-YFP expressed in CHO-K1 cells assessed down-modulation of CD4 surface expression incubated for 24 hrs by flow cytometry | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
2. | ALA4677393 | F | Antiviral activity against HIV-1 NL4-3 infected in human MT-4 cells assessed as inhibition of viral replication by measuring inhibition of cell viability preincubated with cells for 15 mins followed by viral infection and measured after 4 days by MTS/PES assay | Human immunodeficiency virus 1 | 15 | organism-based format | Scientific Literature | ||
3. | ALA4677394 | A | Cytotoxicity against human MT-4 cells assessed as inhibition of cell viability incubated for 48 hrs by MTS/PES assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
4. | ALA4677397 | P | Kinetic solubility of the compound in aqueous PBS buffer at H 7.4/2.5% DMSO incubated for 1 hr by nephelometry | 5 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA5029685 | A | Cytotoxicity against human HEK293T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
6. | ALA5029686 | F | Down modulation of sortilin expression in HEK293T cells tranfected with GFP-tagged sortilin incubated for 24 hrs by flow cytometric analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
7. | ALA5029687 | P | Kinetic solubility of compound at pH 7.4 PBS buffer incubated for 30 mins by nephelometry | 7 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA5029688 | T | Therapeutic index, ratio of CC50 for cytotoxicity against human HEK293T cells to ratio of IC50 for Down modulation of sortilin expression in HEK293T cells tranfected with GFP-tagged sortilin incubated for 24 hrs by flow cytometric analysis | 7 | cell-based format | Scientific Literature | |||
9. | ALA5029691 | F | Inhibition of mammosphere-forming capacity in ER-negative human MDA-MB-231 cells assessed inhibition of as progranulin-induced mammosphere formation at 1 uM measured after 48 hrs by microscopy | Homo sapiens | 5 | tissue-based format | Scientific Literature | ||
10. | ALA5029695 | F | Effect on mammosphere-forming capacity in ER-positive human MCF7 cells measured after 48 hrs by microscopy | Homo sapiens | 7 | tissue-based format | Scientific Literature | ||
11. | ALA5029696 | F | Inhibition of mammosphere-forming capacity in ER-positive human MCF7 cells assessed as inhibition of progranulin-induced mammosphere formation at 4 uM measured after 48 hrs by microscopy | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
12. | ALA5029697 | F | Inhibition of mammosphere-forming capacity in ER-negative human MDA-MB-231 cells assessed as inhibition of progranulin-induced mammosphere formation at 4 uM measured after 48 hrs by microscopy | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
13. | ALA5029698 | F | Effect on mammosphere-forming capacity in ER-negative human MDA-MB-231 cells measured after 48 hrs by microscopy | Homo sapiens | 7 | tissue-based format | Scientific Literature |