| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4712434 | A | Stability in mouse plasma assessed as intact peptide level at 1.56 mM incubated for 1 hr by RP-HPLC analysis | Mus musculus | 5 | cell-free format | Scientific Literature | ||
| 2. | ALA4712435 | A | Stability in mouse plasma assessed as half life at 1.56 mM by RP-HPLC analysis | Mus musculus | 6 | cell-free format | Scientific Literature | ||
| 3. | ALA4712436 | A | Stability in human plasma assessed as half life at 1.56 mM by RP-HPLC analysis | Homo sapiens | 5 | cell-free format | Scientific Literature | ||
| 4. | ALA4712437 | B | Displacement of [Glp65, Nle75, Tyr77][125I]-apelin13 from human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting based radioligand binding assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA4712438 | F | Agonist activity at APJ receptor in rat NRK-52E cells assessed as effect on cAMP accumulation incubated for 1 hr by cAMP-Glo assay | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 6. | ALA4712440 | B | Binding affinity to human APJ receptor expressed in HEK293 cells assessed as reduction in D-biotin-Apelin13 binding incubated for 1 hr by biotin-label based binding affinity assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA4712441 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as improvement in pathologies in injured kidneys dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment by hematoxylin and eosin staining based assay | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 8. | ALA4712442 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as reduction in serum BUN level dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 9. | ALA4712444 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as reduction neutrophil infiltration dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 10. | ALA4712445 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as reduction lymphocyte infiltration dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 11. | ALA4712448 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as reduction N-gal mRNA levels dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment by qPCR analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4712450 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as reduction in fibrosis by measuring collagen deposition dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment by Masson staining based assay | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 13. | ALA4712451 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as reduction in apoptosis by measuring increase in number of TUNEL+ cells dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment by TUNEL assay | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 14. | ALA4712452 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as reduction in p-MLK levels dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment by Western blot analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 15. | ALA4712453 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as reduction in cleaved-caspase-3 levels dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment by Western blot analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 16. | ALA4712454 | F | Reno-protective activity in C57BL/6 mouse model of renal I/R injury assessed as suppression of reduction in cleaved-caspase-8 levels dosed intraperitoneally twice per day for 3 days from day of I/R injury to end of experiment by Western blot analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 17. | ALA4712455 | F | Cytoprotective activity in rat NRK-52E cells assessed as reduction in H/R-injury induced cell death at 300 pM incubated for 24 hrs | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA4712456 | F | Cytoprotective activity in rat NRK-52E cells assessed as reduction in cisplatin-induced cell death at 300 pM incubated for 24 hrs | Rattus norvegicus | 3 | cell-based format | Scientific Literature |
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