# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4672899 | F | Induction in mouse Oli-neu cell differentiation to oligodendrocytes assessed as increase in CNPase expression at 5 uM after 72 hrs by Western blot analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
2. | ALA4672900 | F | Induction in mouse Oli-neu cell differentiation to oligodendrocytes assessed as decrease in Olig2 expression at 5 uM after 72 hrs by Western blot analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
3. | ALA4672901 | F | Induction in mouse Oli-neu cell differentiation to oligodendrocytes assessed as increase in filament length at 5 uM after 48 hrs | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
4. | ALA4672902 | F | Immunomodulatory activity in LPS treated rat primary microglial cells assessed as reduction in nitrite level at 0.5 uM preincubated for 6 hrs by Griess reagent assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
5. | ALA4672903 | A | Prodrug activation in rat brain homogenate assessed as hydrolysis half life after 1 hr in presence of PF-3845 FAAH inhibitor by LC-DAD MS/MS analysis | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
6. | ALA4672904 | F | Neuroprotective activity against glutamate/glycine-induced excitotoxicity in rat primary Cerebellar granule neurone at 25 uM preincubated for 6 hrs measured after 24 hrs by MTT assay | Rattus norvegicus | 4 | tissue-based format | Scientific Literature | ||
7. | ALA4672905 | F | Neuroprotective activity against glutamate/glycine-induced excitotoxicity in rat primary Cerebellar granule neurone at 10 uM preincubated for 6 hrs measured after 24 hrs by MTT assay | Rattus norvegicus | 3 | tissue-based format | Scientific Literature | ||
8. | ALA4672906 | F | Neuroprotective activity against glutamate/glycine-induced excitotoxicity in rat primary Cerebellar granule neurone at 5 uM preincubated for 6 hrs measured after 24 hrs by MTT assay | Rattus norvegicus | 3 | tissue-based format | Scientific Literature | ||
9. | ALA4672907 | F | Induction in mouse Oli-neu cell differentiation to oligodendrocytes assessed as decrease in cell number at 5 uM after 48 hrs | Mus musculus | 3 | tissue-based format | Scientific Literature | ||
10. | ALA4672908 | T | Neurotoxicity in rat primary Cerebellar granule neurone assessed as cell viability at 5 uM measured after 24 hrs by MTT assay | Rattus norvegicus | 6 | tissue-based format | Scientific Literature | ||
11. | ALA4672909 | T | Neurotoxicity in rat primary Cerebellar granule neurone assessed as cell viability at 10 uM measured after 24 hrs by MTT assay | Rattus norvegicus | 6 | tissue-based format | Scientific Literature | ||
12. | ALA4672910 | T | Neurotoxicity in rat primary Cerebellar granule neurone assessed as cell viability at 25 uM measured after 24 hrs by MTT assay | Rattus norvegicus | 6 | tissue-based format | Scientific Literature | ||
13. | ALA4672911 | T | Neurotoxicity in rat primary Cerebellar granule neurone assessed as cell viability at 50 uM measured after 24 hrs by MTT assay | Rattus norvegicus | 6 | tissue-based format | Scientific Literature | ||
14. | ALA4672912 | A | Stability in rat plasma assessed as parent compound remaining after 1 hr by LC-DAD-MS/MS | Rattus norvegicus | 2 | cell-free format | Scientific Literature | ||
15. | ALA4672913 | A | Permeability of the compound on PBS buffer pH 7.4 at 100 uM by PAMPA-BBB assay | 6 | assay format | Scientific Literature | |||
16. | ALA4672914 | A | Prodrug activation in rat brain homogenate assessed as hydrolysis half life after 1 hr by LC-DAD MS/MS analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
17. | ALA4672915 | B | Inhibition of HDAC in human medulloblastoma (DAOY) cells assessed as increase in acetylated histone levels at 1.5 mM after 48 hrs by densitometric analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
18. | ALA4672916 | B | Inhibition of HDAC in human medulloblastoma (DAOY) cells assessed as increase in acetylated histone levels at 0.5 mM after 48 hrs by densitometric analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
19. | ALA4672917 | F | Immunomodulatory activity in LPS treated rat primary microglial cells assessed as shift in M1 neurotoxic phenotype to M2 neuroprotective by measuring decrease in iNOS expression level at 0.5 uM preincubated for 6 hrs by western blot analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
20. | ALA4672918 | F | Immunomodulatory activity in LPS treated rat primary microglial cells assessed as shift in M1 neurotoxic phenotype to M2 neuroprotective by measuring TREM2 expression level at 0.5 uM preincubated for 6 hrs by western blot analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature |