# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4719346 | F | Antiviral activity against HIV-1 BAL infected in human astrocytes assessed as reduction in p24 production at 10 to 1000 nM treated for 1 hr prior to viral infection and measured after 5 days by ELISA | Human immunodeficiency virus 1 | 3 | organism-based format | Scientific Literature | ||
2. | ALA4719349 | F | Antagonist activity at human MOR transfected in CHO cells co-transfected with Gqi5 assessed as inhibition of DAMGO-induced calcium mobilization incubated for 15 mins prior to DAMGO addition and measured for 90 secs by Fluo-4AM dye based fluorescence analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
3. | ALA4719350 | B | Displacement of [3H]NLX from mouse MOR expressed in CHO cell membrane incubated for 90 mins by liquid scintillation spectrophotometry | Mus musculus | 8 | cell membrane format | Scientific Literature | ||
4. | ALA4719351 | F | Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
5. | ALA4719352 | B | Displacement of [125I]MIP-1alpha from CCR5 receptor in rhesus monkey membrane incubated for 120 mins by liquid scintillation counting analysis | Macaca mulatta | 9 | cell membrane format | Scientific Literature | ||
6. | ALA4719353 | F | Antiviral activity against HIV-1 SF162 infected in human astrocytes assessed as reduction in viral invasion by measuring decrease in Tat protein expression at 100 nM treated prior to viral infection and measured after 18 hrs by luciferase based assay | Human immunodeficiency virus 1 | 2 | organism-based format | Scientific Literature | ||
7. | ALA4719354 | B | Binding affinity to CCR5-hMOR heterodimer in CHO cells co-expressing CD4 and luciferase reporter assessed as inhibition of CD4-gp120 complex interaction with receptor dimer by measuring inhibition of cell-cell fusion process at 3000 nM measured after co-incubation of CHO cells with HEK293 cells expressing HIV-1 gp120 and T7 polymerase in presence of compound for 18 hrs by luciferase based luminescence assay | 1 | cell-based format | Scientific Literature | |||
8. | ALA4719355 | F | Agonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as calcium mobilization incubated for 15 mins by Fluo-4AM dye based fluorescence analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
9. | ALA4719356 | F | Antiviral activity against HIV-1 BAL infected in human PBMC assessed as reduction in p24 production at 10 to 1000 nM treated for 1 hr prior to viral infection and measured after 5 days by ELISA | Human immunodeficiency virus 1 | 2 | organism-based format | Scientific Literature | ||
10. | ALA4719358 | F | Antiviral activity against HIV-1 BAL infected in human macrophages assessed as reduction in p24 production at 1 uM treated for 1 hr prior to viral infection and measured after 5 days by ELISA | Human immunodeficiency virus 1 | 3 | organism-based format | Scientific Literature | ||
11. | ALA4719359 | F | Antiviral activity against HIV-1 SF162 infected in human astrocytes assessed as reduction in viral invasion by measuring decrease in Tat protein expression at 100 nM co-treated with morphine prior to viral infection and measured after 18 hrs by luciferase based assay | Human immunodeficiency virus 1 | 2 | organism-based format | Scientific Literature | ||
12. | ALA4719360 | F | Antiviral activity against HIV-1 SF162 infected in human astrocytes assessed as reduction in viral invasion by measuring decrease in Tat protein expression at 100 nM treated prior to viral infection and measured after 18 hrs by luciferase based assay relative to maraviroc | Human immunodeficiency virus 1 | 1 | organism-based format | Scientific Literature | ||
13. | ALA4719361 | F | Antiviral activity against HIV-1 SF162 infected in human astrocytes assessed as reduction in viral invasion by measuring decrease in Tat protein expression at 100 nM treated prior to viral infection and measured after 18 hrs by luciferase based assay relative to maraviroc in presence of morphine | Human immunodeficiency virus 1 | 1 | organism-based format | Scientific Literature | ||
14. | ALA4719362 | B | Binding affinity to CCR5-hMOR heterodimer in CHO cells co-expressing CD4 and luciferase reporter assessed as inhibition of CD4-gp120 complex interaction with receptor dimer by measuring inhibition of cell-cell fusion process at 3000 nM measured after co-incubation of CHO cells with HEK293 cells expressing HIV-1 gp120 and T7 polymerase in presence of compound and morphine for 18 hrs by luciferase based luminescence assay | 1 | cell-based format | Scientific Literature |