# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4685225 | Binding | Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate measured after 2 hrs by ADP-Glo luminescence assay | Homo sapiens | 17 | ALA4680196 | assay format | Scientific Literature | |
2. | ALA4685226 | Functional | Antiproliferative activity against human SU-DHL-6 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 13 | ALA4680196 | cell-based format | Scientific Literature | |
3. | ALA4685227 | Binding | Inhibition of human full-length recombinant N-terminal His-tagged PI3K p110alpha/p85alpha expressed in baculovirus expression system using PIP2 as substrate measured after 2 hrs by ADP-Glo luminescence assay | Homo sapiens | 2 | ALA4680196 | assay format | Scientific Literature | |
4. | ALA4685228 | Binding | Inhibition of human full-length recombinant His-tagged PI3K p110beta/p85beta expressed in baculovirus expression system using PIP2 as substrate measured after 2 hrs by ADP-Glo luminescence assay | Homo sapiens | 2 | ALA4680196 | assay format | Scientific Literature | |
5. | ALA4685229 | Binding | Inhibition of recombinant human full-length His-tagged p110gamma expressed in baculovirus expression system using PIP2 as substrate measured after 2 hrs by ADP-glo assay | Homo sapiens | 2 | ALA4680196 | assay format | Scientific Literature | |
6. | ALA4685230 | Binding | Selectivity ratio of IC50 for inhibition of human full-length recombinant N-terminal His-tagged PI3K p110alpha/p85alpha expressed in baculovirus expression system to IC50 for inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system | Homo sapiens | 2 | ALA4680196 | assay format | Scientific Literature | |
7. | ALA4685231 | Binding | Selectivity ratio of IC50 for inhibition of human full-length recombinant His-tagged PI3K p110beta/p85beta expressed in baculovirus expression system to IC50 for inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system | Homo sapiens | 2 | ALA4680196 | assay format | Scientific Literature | |
8. | ALA4685232 | Binding | Selectivity ratio of IC50 for inhibition of recombinant human full-length His-tagged p110gamma expressed in baculovirus expression system to IC50 for inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system | Homo sapiens | 2 | ALA4680196 | assay format | Scientific Literature | |
9. | ALA4685233 | Binding | Inhibition of PI3K in human SU-DHL-6 cells assessed as reduction in AKT phosphorylation at Ser473 residues after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4680196 | cell-based format | Scientific Literature | |
10. | ALA4685234 | Binding | Inhibition of PI3K in human SU-DHL-6 cells assessed as reduction in S6K1 phosphorylation at Thr389 residues after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4680196 | cell-based format | Scientific Literature | |
11. | ALA4685235 | ADME | Elimination half life in Sprague-Dawley rat at 5 mg/kg, iv by UHPLC-LC/MS analysis | Rattus norvegicus | 1 | ALA4680196 | organism-based format | Scientific Literature | |
12. | ALA4685236 | ADME | AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, iv by UHPLC-LC/MS analysis | Rattus norvegicus | 1 | ALA4680196 | organism-based format | Scientific Literature | |
13. | ALA4685237 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 5 mg/kg, iv or po by UHPLC-LC/MS analysis | Rattus norvegicus | 1 | ALA4680196 | organism-based format | Scientific Literature | |
14. | ALA4685238 | ADME | Clearance in Sprague-Dawley rat at 5 mg/kg, po by UHPLC-LC/MS analysis | Rattus norvegicus | 1 | ALA4680196 | organism-based format | Scientific Literature | |
15. | ALA4685239 | ADME | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg by UHPLC-LC/MS analysis | Rattus norvegicus | 1 | ALA4680196 | organism-based format | Scientific Literature | |
16. | ALA4685240 | ADME | Elimination half life in Sprague-Dawley rat at 5 mg/kg, po by UHPLC-LC/MS analysis | Rattus norvegicus | 1 | ALA4680196 | organism-based format | Scientific Literature | |
17. | ALA4685241 | ADME | AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, po by UHPLC-LC/MS analysis | Rattus norvegicus | 1 | ALA4680196 | organism-based format | Scientific Literature |