# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4670985 | B | Binding affinity to human PD1-L1 (18-134 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr by MST analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
2. | ALA4670986 | B | Binding affinity to mouse PD1-L1 (19-134 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr by MST analysis | Mus musculus | 4 | assay format | Scientific Literature | ||
3. | ALA4670992 | T | Toxicity in human Jurkat cells at >10 uM incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA4670993 | B | Inhibition of hPD-1/hPD-L1 immune checkpoint using PD-L1 expressing human aAPCs and PD-1 expressing human Jurkat cells assessed as activation of effector Jurkat T cells incubated for 6 hrs by luciferase reporter gene based immune checkpoint blockade cell-based assay | 10 | cell-based format | Scientific Literature | |||
5. | ALA4670995 | B | Inhibition of hPD-1/hPD-L1 immune checkpoint using PD-L1 expressing human aAPCs and PD-1 expressing human Jurkat cells assessed as activation of effector Jurkat T cells at 0.01 to 100 uM incubated for 6 hrs by luciferase reporter gene based immune checkpoint blockade cell-based assay | 10 | cell-based format | Scientific Literature | |||
6. | ALA4670999 | B | Binding affinity to human PD1 (34-150 residues) extracellular domain C93S mutant expressed in Escherichia coli BL21 (DE3) incubated for 2 hrs by TR-FRET assay | Homo sapiens | 38 | assay format | Scientific Literature |