# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4729854 | B | Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ms followed by 400 ms voltage ramp to 60 mV by whole cell patch clamp method | Rattus norvegicus | 3 | ALA4725389 | cell-based format | Scientific Literature | |
2. | ALA4729855 | B | Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ms followed by 400 ms voltage ramp to 60 mV by whole cell patch clamp method | Homo sapiens | 4 | ALA4725389 | cell-based format | Scientific Literature | |
3. | ALA4729858 | B | Inhibition of recombinant rat SK2 expressed in HEK293 cells at 100 nM and holding potential at 0 mV and ramp voltage from -100 to 100 mV by whole cell patch clamp method relative to control | Rattus norvegicus | 1 | ALA4725389 | cell-based format | Scientific Literature | |
4. | ALA4729859 | B | Inhibition of recombinant human SK3 expressed in HEK293T cells at 100 nM and holding potential at 0 mV and ramp voltage from -100 to 100 mV by whole cell patch clamp method relative to control | Homo sapiens | 1 | ALA4725389 | cell-based format | Scientific Literature | |
5. | ALA4729861 | B | Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as reduction in channel current with holding potential 0 mV and ramp voltage from -100 to 100 mV by whole cell patch clamp method | Homo sapiens | 3 | ALA4725389 | cell-based format | Scientific Literature | |
6. | ALA4729862 | F | Inhibition of cell migration in human MDA-MB-435 cells transfected with lentivrus-encoding shRNA against SK3 by matrigel invasion method relative to control | Homo sapiens | 3 | ALA4725389 | cell-based format | Scientific Literature | |
7. | ALA4729863 | B | Inhibition of SK3-dependent cell migration in human MDA-MB-435 cells assessed as ratio of total cells migrating by matrigel invasion method relative to control | Homo sapiens | 3 | ALA4725389 | cell-based format | Scientific Literature |