# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4735371 | B | Displacement of UNC5114-biotin tracer ligand from N-terminal 6His-tagged EED (1 to 441 residues) (unknown origin) expressed in Escherichia coli Rosetta2 BL21(DE3)pLysS cells measured after 1 hr by TR-FRET analysis | Homo sapiens | 2 | ALA4732117 | cell-based format | Scientific Literature | |
2. | ALA4735372 | B | Induction of VHL-mediated EED degradation in human HeLa cells at 5 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4732117 | cell-based format | Scientific Literature | |
3. | ALA5104660 | B | PROTAC activity at VHL/PRC2 in human HeLa cells assessed as induction of PRC2 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5104095 | cell-based format | Scientific Literature | |
4. | ALA5104661 | B | PROTAC activity at VHL/PRC2 in human HeLa cells assessed as induction of PRC2 degradation incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5104095 | cell-based format | Scientific Literature | |
5. | ALA5127832 | F | Antiproliferative activity against human DB cells measured after 9 days by tryphan blue staining | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
6. | ALA5127833 | F | Antiproliferative activity against human Pfeiffer cells measured after 3 days by tryphan blue staining | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
7. | ALA5127834 | B | Inhibition of EZH2 (unknown origin) | Homo sapiens | 1 | ALA5126528 | single protein format | Scientific Literature | |
8. | ALA5127835 | B | Inhibition of full length N-terminal His-6x tagged EED (1 to 441 residues) (unknown origin) incubated for 1 hr by TR-FRET assay | Homo sapiens | 2 | ALA5126528 | single protein format | Scientific Literature | |
9. | ALA5127886 | B | Protac activity at VHL/EED in human HeLa cells assessed as degradation of protein measured after 24 hrs by Bradford assay kit method | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
10. | ALA5127887 | B | Protac activity at VHL/EZH2 in human HeLa cells assessed as degradation of protein measured after 24 hrs by Bradford assay kit method | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
11. | ALA5127888 | B | Protac activity at VHL/EED in human DB cells assessed as degradation of protein measured after 24 to 72 hrs by Bradford assay kit method | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
12. | ALA5127889 | B | Protac activity at VHL/SUZ12 in human HeLa cells assessed as degradation of protein measured after 24 hrs by Bradford assay kit method relative to control | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
13. | ALA5127890 | B | Protac activity at VHL/EZH2 in human DB cells assessed as degradation of protein measured after 24 to 72 hrs by Bradford assay kit method | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
14. | ALA5127891 | B | Protac activity at VHL/SUZ12 in human DB cells assessed as degradation of protein measured after 24 to 72 hrs by Bradford assay kit method | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
15. | ALA5127892 | B | Protac activity at VHL/EED in human DB cells assessed as degradation of protein measured after 24 to 72 hrs by Bradford assay kit method relative to control | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
16. | ALA5127893 | B | Protac activity at VHL/EZH2 in human DB cells assessed as degradation of protein measured after 24 to 72 hrs by Bradford assay kit method relative to control | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
17. | ALA5127894 | B | Protac activity at VHL/SUZ12 in human DB cells assessed as degradation of protein measured after 24 to 72 hrs by Bradford assay kit method relative to control | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
18. | ALA5127895 | F | Antiproliferative activity against human DB cells assessed as viable cells with replenishment of medium with compound for every three days upto 9 days by trypan blue staining based automated bio-rad TC20 cell counter method | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
19. | ALA5127896 | F | Antiproliferative activity against human Pfeiffer cells assessed as viable cells with replenishment of medium with compound for every three days upto 6 days by trypan blue staining based automated bio-rad TC20 cell counter method | Homo sapiens | 1 | ALA5126528 | cell-based format | Scientific Literature | |
20. | ALA5231249 | B | PROTAC activity at PRC2 catalytic core EED/VHL (unknown origin) measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5230109 | protein format | Scientific Literature |