| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4676181 | B | Antagonist activity at human GnRH receptor expressed in CHO-K1 cells assessed as inhibition of LHRH-induced response preincubated for 20 mins followed by LHRH addition and measured after 60 mins by TR-FRET assay | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
| 2. | ALA4676182 | B | Antagonist activity at human GnRH receptor expressed in CHO-K1 cells assessed as inhibition of buserelin-induced response preincubated for 20 mins followed by buserelin addition and measured after 60 mins by TR-FRET assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 3. | ALA4676183 | B | Antagonist activity at rat GnRH receptor expressed in CHO-K1 cells assessed as inhibition of LHRH-induced response preincubated for 20 mins followed by LHRH addition and measured after 60 mins by TR-FRET assay | Rattus norvegicus | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA4676184 | B | Antagonist activity at rat GnRH receptor expressed in CHO-K1 cells assessed as inhibition of buserelin-induced response preincubated for 20 mins followed by buserelin addition and measured after 60 mins by TR-FRET assay | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA4676186 | A | Intrinsic clearance in Han Wistar rat hepatocytes at 1 uM measured up to 90 mins by LC/MS/MS analysis | Rattus norvegicus | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA4676191 | A | Clearance in Wistar rat at 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 7. | ALA4676192 | A | Half life in Wistar rat at 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 8. | ALA4676193 | A | Oral bioavailability in Wistar rat at 2 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature |
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