# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4724037 | B | Inhibition of PI3Kalpha (unknown origin) at 100 nM using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to control | Homo sapiens | 33 | ALA4715876 | single protein format | Scientific Literature | |
2. | ALA4724038 | B | Inhibition of PI3Kalpha (unknown origin) at 1 uM using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to control | Homo sapiens | 33 | ALA4715876 | single protein format | Scientific Literature | |
3. | ALA4724039 | B | Inhibition of PI3Kdelta (unknown origin) at 100 nM using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to control | Homo sapiens | 33 | ALA4715876 | single protein format | Scientific Literature | |
4. | ALA4724040 | B | Inhibition of PI3Kdelta (unknown origin) at 1 uM using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to control | Homo sapiens | 33 | ALA4715876 | single protein format | Scientific Literature | |
5. | ALA4724041 | B | Inhibition of PI3Kalpha in human MDA-MB-453 cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assay | Homo sapiens | 28 | ALA4715876 | cell-based format | Scientific Literature | |
6. | ALA4724042 | B | Inhibition of PI3Kalpha in human MDA-MB-453 cells assessed as reduction in phosphorylation of AKT at 473 at 10 uM measured after 1 hr by alpha screen assay | Homo sapiens | 13 | ALA4715876 | cell-based format | Scientific Literature | |
7. | ALA4724043 | B | Inhibition of PI3Kbeta in human 786-O cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assay | Homo sapiens | 34 | ALA4715876 | cell-based format | Scientific Literature | |
8. | ALA4724044 | B | Inhibition of PI3Kgamma in mouse RAW 264.7 cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assay | Mus musculus | 34 | ALA4715876 | cell-based format | Scientific Literature | |
9. | ALA4724045 | B | Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assay | Homo sapiens | 34 | ALA4715876 | cell-based format | Scientific Literature | |
10. | ALA4724046 | A | Stability of compound in mouse liver microsome assessed as parent compound remaining at 1 uM measured after 30 mins in presence of NADPH by LC/MS/MS analysis | Mus musculus | 33 | ALA4715876 | microsome format | Scientific Literature | |
11. | ALA4724047 | A | Stability of compound in rat liver microsome assessed as parent compound remaining at 1 uM measured after 30 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 33 | ALA4715876 | microsome format | Scientific Literature | |
12. | ALA4724048 | A | Stability of compound in human liver microsome assessed as parent compound remaining at 1 uM measured after 30 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 33 | ALA4715876 | microsome format | Scientific Literature |