| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4713701 | B | Protac activity at CRBN/ZFP91 in human BxPC-3 cells assessed as induction of ZF91 degradation incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4713702 | F | Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 3 days by MTT assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 3. | ALA4713703 | F | Antiproliferative activity against human BxPC-3 cells assessed as reduction in cell viability incubated for 3 days by MTT assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 4. | ALA4713717 | B | Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK293 cells expressing SIE-luc2P preincubated for overnight followed by IL-6 stimulation and measured after 24 hr by Bio-Glo luciferase reagent based microplate reader assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA4713718 | F | Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 6. | ALA4713719 | U | Selectivity index, ratio of IC50 for antiproliferative activity against human HEK293 cell by MTT assay to IC50 for inhibition of IL-6 induced STAT3 transcription in human HEK293 cells | 1 | cell-based format | Scientific Literature | |||
| 7. | ALA4713720 | B | Protac activity at CRBN/STAT3 in human BxPC-3 cells assessed as decrease in STAT3 expression level at 5 uM after 16 hrs by western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4713721 | B | Inhibition of STAT3 phosphorylation in human BxPC-3 cells at 1 uM after 16 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4713726 | B | Inhibition of STAT3 phosphorylation in human MIA PaCa-2 cells at 0.5 to 1 uM after 16 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4713727 | F | Effect on NQO1 expression in human MIA PaCa-2 cells at 0.0.5 to 1 uM incubated for 16 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4713730 | B | Protac activity at CRBN/STAT3 in human BxPC-3 cells assessed as decrease in STAT3 expression level at 2 to 6 uM incubated for 12 hrs in presence of proteasome inhibitor MG132 by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4713732 | F | Reduction in NQO1 expression in human BxPC-3 cells at 2 to 6 uM incubated for 12 hrs in presence of proteasome inhibitor MG132 by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4713735 | B | Protac activity at CRBN/STAT3 in human BxPC-3 cells assessed as increase in inhibition of STAT3 protein levels at 2 to 3 uM incubated for 16 hrs in presence of protein synthesis inhibitor cycloheximide by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4713736 | F | Reduction in NQO1 expression in human BxPC-3 cells at 2 to 6 uM incubated for 12 hrs in presence of protein synthesis inhibitor cycloheximide by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4713737 | B | Protac activity at CRBN/ZFP91 in human BxPC-3 cells assessed as induction of ZF91 degradation at 1 uM incubated for 16 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4713739 | B | Protac activity at CRBN/ZFP91 in human BxPC-3 cells assessed as induction of ZF91 degradation incubated for 16 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4713740 | B | Protac activity at CRBN/ZFP91 in human BxPC-3 cells assessed as induction of ZF91 degradation incubated for 4 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4713741 | B | Protac activity at CRBN/ZFP91 in human BxPC-3 cells assessed as ZF91 protein degradation at 1 uM incubated for 16 hrs in presence of proteasome inhibitor carfilzomib by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4713742 | B | Protac activity at CRBN/ZFP91 in human MIA PaCa-2 cells assessed as ZF91 protein degradation at 0.1 to 0.5 uM incubated for 16 hrs in presence of proteasome inhibitor carfilzomib by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4713743 | B | Protac activity at CRBN/ZFP91 in human BxPC-3 cells assessed as degradation of ZFP91 at 0.5 uM incubated for 16 hrs in presence of napabucasin by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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