# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4719886 | Binding | Agonist activity at human S1P3 expressed in EDG3-Ga15-bla HEK293T cells incubated for 45 mins by scintillation counting based [35S]GTP-gamma-S binding assay relative to control | Homo sapiens | 4 | ALA4715806 | cell membrane format | Scientific Literature | |
2. | ALA4719889 | Functional | Induction of lymphopenia in Balb/c mouse assessed as reduction of circulating lymphocytes at 1 mg/kg, po measured after 4 hrs relative to control | Mus musculus | 2 | ALA4715806 | organism-based format | Scientific Literature | |
3. | ALA4719890 | Functional | Induction of lymphopenia in Balb/c mouse assessed as reduction of circulating lymphocytes at 1 mg/kg, po measured after 24 hrs relative to control | Mus musculus | 2 | ALA4715806 | organism-based format | Scientific Literature | |
4. | ALA4719891 | Functional | Induction of lymphopenia in Balb/c mouse assessed as reduction of circulating lymphocytes at 10 mg/kg, po measured after 4 hrs relative to control | Mus musculus | 2 | ALA4715806 | organism-based format | Scientific Literature | |
5. | ALA4719892 | Functional | Induction of lymphopenia in Balb/c mouse assessed as reduction of circulating lymphocytes at 10 mg/kg, po measured after 24 hrs relative to control | Mus musculus | 2 | ALA4715806 | organism-based format | Scientific Literature | |
6. | ALA4719894 | Binding | Inhibition of human ERG expressed in HEK293 cells assessed as inhibition of peak tail current at 0.3 uM by patch clamp analysis | Homo sapiens | 2 | ALA4715806 | cell-based format | Scientific Literature | |
7. | ALA4719895 | Binding | Inhibition of sodium channel (unknown origin) assessed as reduction in Na+ flux | Homo sapiens | 2 | ALA4715806 | assay format | Scientific Literature | |
8. | ALA4719896 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA4715806 | single protein format | Scientific Literature | |
9. | ALA4719897 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | ALA4715806 | single protein format | Scientific Literature | |
10. | ALA4719898 | ADME | Inhibition of CYP2C8 (unknown origin) | Homo sapiens | 2 | ALA4715806 | single protein format | Scientific Literature | |
11. | ALA4719899 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | ALA4715806 | single protein format | Scientific Literature | |
12. | ALA4719900 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 2 | ALA4715806 | single protein format | Scientific Literature | |
13. | ALA4719901 | ADME | Half life in human liver microsomes | Homo sapiens | 2 | ALA4715806 | microsome format | Scientific Literature | |
14. | ALA4719902 | ADME | Half life in rat liver microsomes | Rattus norvegicus | 2 | ALA4715806 | microsome format | Scientific Literature | |
15. | ALA4719903 | ADME | Half life in mouse liver microsomes | Mus musculus | 2 | ALA4715806 | microsome format | Scientific Literature | |
16. | ALA4719904 | ADME | Half life in monkey liver microsomes | Macaca mulatta | 2 | ALA4715806 | microsome format | Scientific Literature | |
17. | ALA4719905 | ADME | Unbound fraction in human plasma | Homo sapiens | 2 | ALA4715806 | cell-free format | Scientific Literature | |
18. | ALA4719906 | ADME | Unbound fraction in rat plasma | Rattus norvegicus | 2 | ALA4715806 | cell-free format | Scientific Literature | |
19. | ALA4719907 | ADME | Unbound fraction in mouse plasma | Mus musculus | 2 | ALA4715806 | cell-free format | Scientific Literature | |
20. | ALA4719908 | ADME | Unbound fraction in cynomolgus monkey plasma | Macaca fascicularis | 2 | ALA4715806 | cell-free format | Scientific Literature |