#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4688478	Binding	Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Fluo-4 AM dye based fluorescence analysis	Homo sapiens	22	ALA4680310	cell-based format	Scientific Literature
2.	ALA4688479	ADME	Drug metabolism in human liver microsomes assessed as dansyl glutathione adduct formation at 100 microM incubated for 30 mins by HPLC/MS based fluorescence analysis relative to diclofenac dGSH adduct	Homo sapiens	22	ALA4680310	microsome format	Scientific Literature
3.	ALA4688481	ADME	Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxymidazolam formation using midazolam as substrate at 10 uM preincubated with enzyme and NADPH followed by substrate addition and measured after 10 mins by HPLC/MS-MS analysis relative to control	Homo sapiens	5	ALA4680310	microsome format	Scientific Literature
4.	ALA4688482	ADME	Induction of CYP3A4 mRNA expression in human HepaRG cells assessed as fold increase in mRNA expression at 3 uM incubated for 24 hrs by real time PCR analysis relative to control	Homo sapiens	5	ALA4680310	cell-based format	Scientific Literature
5.	ALA4688483	Binding	Antagonist activity at rat TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Fluo-4 AM dye based fluorescence analysis	Rattus norvegicus	1	ALA4680310	cell-based format	Scientific Literature
6.	ALA4688484	Functional	In vivo antagonist activity at TRPM8 in Sprague-Dawley rat assessed as inhibition of icilin-induced wet dog shakes at 3 mg/kg, po administered 1 hr prior to icilin administration and measured after 5 mins for 5 mins	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
7.	ALA4688486	Functional	Inhibition of overactive bladder activity in Sprague-Dawley rat assessed as inhibition of cold-induced voiding behaviour by measuring mean voided volume at 3 mg/kg, po administered 1 hr prior to cold exposure and measured at 2 mins interval for 4 hrs (Rvb = 0.57 +/- 0.05 ml)	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
8.	ALA4688488	Functional	Inhibition of overactive bladder activity in Sprague-Dawley rat assessed as inhibition of cold-induced voiding behaviour by measuring reduction in voiding frequency at 3 mg/kg, po administered 1 hr prior to cold exposure and measured at 2 mins interval for 4 hrs	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
9.	ALA4688490	Functional	Inhibition of overactive bladder activity in Sprague-Dawley rat assessed as inhibition of cold-induced voiding behaviour by measuring total voided volume at 3 mg/kg, po administered 1 hr prior to cold exposure and measured at 2 mins interval for 4 hrs (Rvb = 5.57 +/-0.27 ml)	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
10.	ALA4688492	ADME	Cmax in Sprague-Dawley rat at 3 mg/kg, po measured upto 6 hrs by LC-MS/MS analysis	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
11.	ALA4688493	ADME	Tmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
12.	ALA4688494	ADME	AUC (0 to infinity) in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
13.	ALA4688495	ADME	AUC (0 to infinity) in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
14.	ALA4688496	ADME	Half life in Sprague Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
15.	ALA4688497	ADME	Total clearance in Sprague-Dawley rat at 1 mg/kg, iv measured upto 6 hrs by LC-MS/MS analysis	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
16.	ALA4688498	ADME	Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv measured upto 6 hrs by LC-MS/MS analysis	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
17.	ALA4688499	ADME	Oral bioavailability in Sprague-Dawley rat at 3 mg/kg measured upto 6 hrs by LC-MS/MS analysis	Rattus norvegicus	1	ALA4680310	organism-based format	Scientific Literature
18.	ALA4688500	ADME	Drug uptake in rat brain measured after 4 hrs	Rattus norvegicus	2	ALA4680310	tissue-based format	Scientific Literature
19.	ALA4688501	ADME	Plasma concentration in rat measured after 4 hrs	Rattus norvegicus	2	ALA4680310	cell-free format	Scientific Literature
20.	ALA4688502	ADME	Ratio of drug level in rat brain to plasma measured after 4 hrs	Rattus norvegicus	2	ALA4680310	cell-free format	Scientific Literature