| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4711175 | B | Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Boc-Lys(epsilon-Ac)-AMC as substrate measured after 90 mins by fluorescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4711176 | B | Inhibition of recombinant human full-length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-Ac)-AMC as substrate measured after 90 mins by fluorescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA4711177 | B | Inhibition of human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-Ac)-AMC as substrate measured after 90 mins by fluorescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 4. | ALA4711185 | B | Protac activity at CRBN/HDAC3 in mouse RAW264.7 cells assessed as induction of HDAC3 degradation measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4711186 | B | Protac activity at CRBN/HDAC1 in mouse RAW264.7 cells assessed as induction of HDAC1 degradation at 0.01 to 10 uM measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4711187 | B | Protac activity at CRBN/HDAC2 in mouse RAW264.7 cells assessed as induction of HDAC2 degradation at 0.01 to 10 uM measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4711188 | B | Protac activity at CRBN/HDAC3 in mouse RAW264.7 cells assessed as induction of HDAC3 degradation at 10 uM measured after 6 to 48 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4711189 | B | Protac activity at CRBN/HDAC3 in mouse RAW264.7 cells assessed as increase of H3K27 acetylation at 10 uM measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4711190 | B | Protac activity at CRBN/HDAC3 in mouse RAW264.7 cells assessed as induction of HDAC3 degradation at 10 uM measured after 24 hrs in presence of HDAC ligand CI994 by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4711191 | B | Protac activity at CRBN/HDAC3 in mouse RAW264.7 cells assessed as induction of HDAC3 degradation at 10 uM measured after 24 hrs in presence of CRBN ligand pomalidomide by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4711192 | B | Protac activity at CRBN/HDAC3 in mouse RAW264.7 cells assessed as induction of HDAC3 degradation at 10 uM measured after 24 hrs in presence of proteasome inhibitor bortezomib by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4711197 | F | Effect on LPS/IFNgamma-induced IL-10 mRNA expression in mouse RAW264.7 cells at 1 uM incubated for 20 hrs followed by LPS/IFNgamma stimulation and measured after 4 hrs by RT-qPCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4711198 | A | Down regulation of NFkappaB p65 expression in LPS/IFNgamma-induced mouse RAW264.7 cells at 10 uM incubated for 20 hrs followed by LPS/IFNgamma stimulation and measured after 4 hrs by Western blot analysis | Mus musculus | 4 | tissue-based format | Scientific Literature |
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