| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4713462 | Toxicity | Toxicity in lean Sprague-Dawley rat assessed as induction of emesis at 0.3 to 60 nmol/kg dosed daily for 2 days by kaolin consumption assay | Rattus norvegicus | 3 | ALA4706662 | organism-based format | Scientific Literature | |
| 2. | ALA4713463 | Functional | Effect on glucose clearance in Sprague-Dawley rat model of DIO at 10 nmol/kg dosed daily for 5 days | Rattus norvegicus | 1 | ALA4706662 | organism-based format | Scientific Literature | |
| 3. | ALA4713464 | Functional | Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation by FRET assay | Homo sapiens | 10 | ALA4706662 | cell-based format | Scientific Literature | |
| 4. | ALA4713465 | Functional | Agonist activity at human NPY2R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay | Homo sapiens | 10 | ALA4706662 | cell-based format | Scientific Literature | |
| 5. | ALA4713466 | Functional | Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay | Homo sapiens | 10 | ALA4706662 | cell-based format | Scientific Literature | |
| 6. | ALA4713467 | Functional | Agonist activity at rat glucagon receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation by FRET assay | Rattus norvegicus | 10 | ALA4706662 | cell-based format | Scientific Literature | |
| 7. | ALA4713468 | Functional | Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation in presence of GLP-1R antagonist exendin9-39 by FRET assay | Homo sapiens | 1 | ALA4706662 | cell-based format | Scientific Literature | |
| 8. | ALA4713469 | Functional | Agonist activity at human NPY2R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation in presence of NPY2-R antagonist BITE0246 by FRET assay | Homo sapiens | 1 | ALA4706662 | cell-based format | Scientific Literature | |
| 9. | ALA4713470 | Functional | Agonist activity at rat GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation by FRET assay | Rattus norvegicus | 2 | ALA4706662 | cell-based format | Scientific Literature | |
| 10. | ALA4713471 | Binding | Displacement of GLP-1-red from human GLP-1R expressed in CHO-K1 cells by fluorescent competitive binding assay | Homo sapiens | 7 | ALA4706662 | cell-based format | Scientific Literature | |
| 11. | ALA4713472 | Functional | Stimulation of glucose stimulated insulin secretion in rat pancreatic islets at 50 nM in presence of 10 mM glucose incubated for 60 mins | Rattus norvegicus | 3 | ALA4706662 | tissue-based format | Scientific Literature | |
| 12. | ALA4713473 | Functional | Stimulation of glucose stimulated insulin secretion in rat pancreatic islets at 50 nM in presence of 3 mM glucose incubated for 60 mins | Rattus norvegicus | 3 | ALA4706662 | tissue-based format | Scientific Literature | |
| 13. | ALA4713474 | ADME | Half life in Sprague-Dawley rat liver microsomes at 30 uM in presence of NADPH by HPLC analysis | Rattus norvegicus | 3 | ALA4706662 | microsome format | Scientific Literature | |
| 14. | ALA4713475 | ADME | Intrinsic clearance in Sprague-Dawley rat liver microsomes at 30 uM in presence of NADPH by HPLC analysis | Rattus norvegicus | 3 | ALA4706662 | microsome format | Scientific Literature | |
| 15. | ALA4713477 | Functional | Suppression of cumulative food intake in lean Sprague-Dawley rat at 10 to 20 nmol/kg dosed daily for 2 days relative to control | Rattus norvegicus | 1 | ALA4706662 | organism-based format | Scientific Literature | |
| 16. | ALA4713478 | Functional | Suppression of cumulative food intake in lean Sprague-Dawley rat at 0.3 to 60 nmol/kg dosed daily for 2 days | Rattus norvegicus | 1 | ALA4706662 | organism-based format | Scientific Literature | |
| 17. | ALA4713479 | Functional | Suppression of food intake in Sprague-Dawley rat model of DIO at 10 nmol/kg dosed daily for 5 days | Rattus norvegicus | 1 | ALA4706662 | organism-based format | Scientific Literature | |
| 18. | ALA4713480 | Functional | Suppression of body weight in Sprague-Dawley rat model of DIO at 10 nmol/kg dosed daily for 5 days | Rattus norvegicus | 1 | ALA4706662 | organism-based format | Scientific Literature | |
| 19. | ALA4713481 | Functional | Suppression of fasting blood glucose in Sprague-Dawley rat model of DIO at 10 nmol/kg dosed daily for 5 days | Rattus norvegicus | 1 | ALA4706662 | organism-based format | Scientific Literature | |
| 20. | ALA4713482 | Functional | Suppression of blood glucose level in prediabetic Sprague-Dawley rat model of DIO assessed as reduction in post-dextrose bolus blood glucose at 10 nmol/kg dosed daily for 5 days by IPGTT method | Rattus norvegicus | 2 | ALA4706662 | organism-based format | Scientific Literature |
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