# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4707513 | B | Inhibition of human ERG stably expressed in CHO cells after 4 mins | Homo sapiens | 1 | ALA4706482 | cell-based format | Scientific Literature | |
2. | ALA4707514 | A | Apparent permeability across apical to basal side in human Caco2 cells at 10 uM after 90 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4706482 | cell-based format | Scientific Literature | |
3. | ALA4707515 | A | Efflux ratio in across basolateral to apical side over apical to basolateral side in human Caco2 cells at 10 uM after 90 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4706482 | cell-based format | Scientific Literature | |
4. | ALA4707516 | A | Protein binding in mouse plasma | Mus musculus | 1 | ALA4706482 | cell-free format | Scientific Literature | |
5. | ALA4707517 | A | Protein binding in rat plasma | Rattus norvegicus | 1 | ALA4706482 | cell-free format | Scientific Literature | |
6. | ALA4707518 | A | Half life in rat liver microsomes at 1 uM preincubated for 10 mins followed by NADPH addition and measured up to 60 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706482 | microsome format | Scientific Literature | |
7. | ALA4707519 | A | Intrinsic clearance in rat liver microsomes at 1 uM preincubated for 10 mins followed by NADPH addition and measured up to 60 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706482 | microsome format | Scientific Literature | |
8. | ALA4707520 | A | Protein binding in human plasma | Homo sapiens | 1 | ALA4706482 | cell-free format | Scientific Literature | |
9. | ALA4707521 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4706482 | microsome format | Scientific Literature | |
10. | ALA4707522 | F | Antagonist activity at CCR6 in human CD4-positive cells assessed as inhibition of CCL20-induced calcium signal up to 10000 nM by FLIPR assay | Homo sapiens | 1 | ALA4706482 | cell-based format | Scientific Literature | |
11. | ALA4707523 | F | Antagonist activity at CXCR1 (unknown origin) stably expressed in HEK293 cells assessed as reduction in IL-8-induced intracellular calcium change up to 10000 nM incubated for 15 mins followed by IL-8-stimulation and measured after 15 mins by cAMP-d2/Eu-Anti-cAM based fluorescence assay | Homo sapiens | 1 | ALA4706482 | cell-based format | Scientific Literature | |
12. | ALA4707525 | F | Antagonist activity at CXCR4 in human CD4-positive T cells assessed as inhibition of CXCL12-induced calcium signal incubated for 20 mins by FLIPR assay | Homo sapiens | 2 | ALA4706482 | cell-based format | Scientific Literature | |
13. | ALA4707526 | A | Cytotoxicity against MEF cells assessed as reduction in cell viability up to 1000 nM by CellTiter-Glo assay | Mus musculus | 1 | ALA4706482 | cell-based format | Scientific Literature | |
14. | ALA4707527 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4706482 | microsome format | Scientific Literature | |
15. | ALA4707528 | F | Cytotoxicity against human Hepa1-6 cells assessed as reduction in cell viability up to 1000 nM by CellTiter-Glo assay | Homo sapiens | 1 | ALA4706482 | cell-based format | Scientific Literature | |
16. | ALA4707529 | A | Cytotoxicity against mouse L929 cells assessed as reduction in cell viability up to 1000 nM by CellTiter-Glo assay | Mus musculus | 1 | ALA4706482 | cell-based format | Scientific Literature | |
17. | ALA4707530 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability up to 1000 nM by CellTiter-Glo assay | Homo sapiens | 1 | ALA4706482 | cell-based format | Scientific Literature | |
18. | ALA4707531 | B | Antagonist activity at CCR4 in human MDA-MB-231 cells assessed as inhibition of CCL12-mediated chemotaxis at 100 nM after 22 hrs by transwell assay | Homo sapiens | 2 | ALA4706482 | cell-based format | Scientific Literature | |
19. | ALA4707532 | B | Antagonist activity at CXCR4 in human HPBALL cells assessed as inhibition of APC-conjugate clone 12G5 antibody signal incubated for 3 hrs by flow cytometric analysis | Homo sapiens | 40 | ALA4706482 | cell-based format | Scientific Literature | |
20. | ALA4773455 | A | Intrinsic clearance in rat liver microsomes at 1 uM peincubated for 10 mins followed by NADPH addition and measured 60 mins by LC-MS/MS analysis | Rattus norvegicus | 16 | ALA4765416 | microsome format | Scientific Literature |