# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4719626 | Functional | Induction of type I IFN production in mouse RAW-Lucia ISG-KO-STING cells at 0.08 to 60 ug/ml incubated for 48 hrs by luciferase reporter gene assay | Mus musculus | 12 | ALA4715794 | tissue-based format | Scientific Literature | |
2. | ALA4719627 | ADME | Stability in presence of nuclease P1 assessed as parent compound remaining level at 7 ug incubated for 2 hrs by HPLC analysis | Penicillium citrinum | 4 | ALA4715794 | single protein format | Scientific Literature | |
3. | ALA4719629 | Binding | Activation of STING in human blood assessed as increase in IL-1 production at 10 ug/ml incubated for 18 to 20 hrs by QUANTI-Blue assay | Homo sapiens | 2 | ALA4715794 | tissue-based format | Scientific Literature | |
4. | ALA4719631 | ADME | Stability in presence of snake venom phosphodiesterase assessed as parent compound remaining level at 7 ug incubated for 2 hrs by HPLC analysis | Not specified | 7 | ALA4715794 | assay format | Scientific Literature | |
5. | ALA4719632 | ADME | Stability in presence of snake venom phosphodiesterase assessed as parent compound remaining level at 7 ug incubated for >2 hrs by HPLC analysis | Not specified | 2 | ALA4715794 | assay format | Scientific Literature | |
6. | ALA4719633 | Binding | Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I IFNs stimulation by measuring induction of IRF pathway incubated for 48 hrs by luciferase reporter gene assay | Mus musculus | 13 | ALA4715794 | cell-based format | Scientific Literature | |
7. | ALA4719634 | Binding | Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I IFNs stimulation by measuring induction of IRF pathway incubated for 48 hrs by luciferase reporter gene assay assay relative to 2',3'-cGAMP | Mus musculus | 12 | ALA4715794 | cell-based format | Scientific Literature | |
8. | ALA4719635 | Binding | Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of IRF pathway incubated for 48 hrs by luciferase reporter gene assay | Homo sapiens | 13 | ALA4715794 | cell-based format | Scientific Literature | |
9. | ALA4719636 | Binding | Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of IRF pathway incubated for 48 hrs by luciferase reporter gene assay relative to 2',3'-cGAMP | Homo sapiens | 12 | ALA4715794 | cell-based format | Scientific Literature | |
10. | ALA4719637 | Binding | Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of NF-kappaB pathway incubated for 48 hrs by luciferase reporter gene assay | Homo sapiens | 13 | ALA4715794 | cell-based format | Scientific Literature | |
11. | ALA4719638 | Binding | Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of NF-kappaB pathway incubated for 48 hrs by luciferase reporter gene assay relative to 2',3'-cGAMP | Homo sapiens | 12 | ALA4715794 | cell-based format | Scientific Literature | |
12. | ALA4719639 | Binding | Activation of STING in human blood assessed as induction of type I IFNs incubated for 18 to 20 hrs by QUANTI-Blue assay | Homo sapiens | 13 | ALA4715794 | tissue-based format | Scientific Literature | |
13. | ALA4719640 | Binding | Activation of STING in human blood assessed as induction of type I IFNs incubated for 18 to 20 hrs by QUANTI-Blue assay relative to 2',3'-cGAMP | Homo sapiens | 12 | ALA4715794 | tissue-based format | Scientific Literature |