# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4737518 | Functional | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay | Homo sapiens | 42 | ALA4732190 | cell-based format | Scientific Literature | |
2. | ALA4737519 | Functional | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay relative to relaxin | Homo sapiens | 42 | ALA4732190 | cell-based format | Scientific Literature | |
3. | ALA4737527 | ADME | Half life in Sprague-Dawley rat at 1 mg/kg, iv measured upto 72 hrs by LC-HRMS analysis | Rattus norvegicus | 13 | ALA4732190 | organism-based format | Scientific Literature | |
4. | ALA4737528 | Functional | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins in presence of 2 % HSA by HTRF assay | Homo sapiens | 11 | ALA4732190 | cell-based format | Scientific Literature |