# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4736493 | F | Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay | Homo sapiens | 33 | ALA4732153 | cell-based format | Scientific Literature | |
2. | ALA4736494 | F | Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay | Homo sapiens | 33 | ALA4732153 | cell-based format | Scientific Literature | |
3. | ALA4736495 | F | Antiproliferative activity against human M21 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay | Homo sapiens | 33 | ALA4732153 | cell-based format | Scientific Literature | |
4. | ALA4736496 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay | Homo sapiens | 33 | ALA4732153 | cell-based format | Scientific Literature | |
5. | ALA4736497 | F | Cell cycle arrest in human M21 cells assessed as accumulation at SubG1 phase at 2 to 5 times IC50 measured after 24 hrs by DAPI staining based flow cytometry (Rvb = 5%) | Homo sapiens | 11 | ALA4732153 | cell-based format | Scientific Literature | |
6. | ALA4736498 | F | Cell cycle arrest in human M21 cells assessed as accumulation at G0/G1 phase at 2 to 5 times IC50 measured after 24 hrs by DAPI staining based flow cytometry (Rvb = 65.5%) | Homo sapiens | 11 | ALA4732153 | cell-based format | Scientific Literature | |
7. | ALA4736499 | F | Cell cycle arrest in human M21 cells assessed as accumulation at S phase at 2 to 5 times IC50 measured after 24 hrs by DAPI staining based flow cytometry (Rvb = 16.1%) | Homo sapiens | 11 | ALA4732153 | cell-based format | Scientific Literature | |
8. | ALA4736500 | F | Cell cycle arrest in human M21 cells assessed as accumulation at G2/M phase at 2 to 5 times IC50 measured after 24 hrs by DAPI staining based flow cytometry (Rvb = 13.4%) | Homo sapiens | 11 | ALA4732153 | cell-based format | Scientific Literature | |
9. | ALA4736506 | B | Disruption of microtubule polymerization in human M21 cells at 5 times IC50 measured after 24 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 6 | ALA4732153 | cell-based format | Scientific Literature | |
10. | ALA4736507 | B | Disruption of microtubule polymerization in human M21 cells assessed as induction of mitotic abnormalities at 5 times IC50 measured after 24 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 6 | ALA4732153 | cell-based format | Scientific Literature | |
11. | ALA4736509 | P | Solubility of compound in DMSO at 30 uM | 1 | ALA4732153 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4736512 | B | Inhibition of porcine brain tubulin polymerization at 30 uM measured after 60 mins by fluorescence assay | Sus scrofa | 1 | ALA4732153 | assay format | Scientific Literature | |
13. | ALA4736515 | B | Inhibition of EBI binding to colchicine-binding site of beta-tubulin in human M21 cells at 100 to 1000 times IC50 preincubated for 2 hrs followed by EBI addition and measured after 1.5 hrs by Western blot analysis | Homo sapiens | 7 | ALA4732153 | cell-based format | Scientific Literature | |
14. | ALA4736516 | T | Toxicity in chick embryo assessed as weight of embryo at 20 ug, iv incubated for 7 days relative to control | Cricetulus griseus | 1 | ALA4732153 | organism-based format | Scientific Literature | |
15. | ALA4736519 | T | Toxicity in chick embryo assessed as death at 20 ug, iv incubated for 7 days relative to control | Cricetulus griseus | 1 | ALA4732153 | organism-based format | Scientific Literature |