# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4712196 | F | Antiproliferative activity against human NCI-H3122 cells at 0.014 to 3.33 uM incubated for 3 days by WST8 assay | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature | |
2. | ALA4712206 | B | Protac activity at VHL/MEK1 in human HT-29 cells assessed as induction of MEK1 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 5 | ALA4706631 | cell-based format | Scientific Literature | |
3. | ALA4712207 | B | Protac activity at VHL/MEK2 in human HT-29 cells assessed as induction of MEK2 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 5 | ALA4706631 | cell-based format | Scientific Literature | |
4. | ALA4712234 | B | Protac activity at VHL/MEK1 in human SK-MEL-28 cells assessed as induction of MEK1 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
5. | ALA4712235 | B | Protac activity at VHL/MEK2 in human SK-MEL-28 cells assessed as induction of MEK2 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
6. | ALA4712236 | B | Inhibition of ERK phosphorylation in human HT-29 cells at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4706631 | cell-based format | Scientific Literature | |
7. | ALA4712237 | B | Inhibition of MEK2 phosphorylation in human HT-29 cells at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4706631 | cell-based format | Scientific Literature | |
8. | ALA4712238 | B | Inhibition of MEK1 phosphorylation in human HT-29 cells at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4706631 | cell-based format | Scientific Literature | |
9. | ALA4712270 | B | Binding affinity to MEK1 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assay | Homo sapiens | 7 | ALA4706631 | single protein format | Scientific Literature | |
10. | ALA4712271 | B | Binding affinity to MEK2 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assay | Homo sapiens | 7 | ALA4706631 | single protein format | Scientific Literature | |
11. | ALA4712272 | F | Effect on global proteome expression in human HT-29 cells at 0.1 uM incubated for 8 hrs by mass spectrometry analysis based global proteome analysis | Homo sapiens | 1 | ALA4706631 | cell-based format | Scientific Literature | |
12. | ALA4712280 | F | Antiproliferative activity against human SK-MEL-28 cells incubated for 3 days by WST8 assay | Homo sapiens | 7 | ALA4706631 | cell-based format | Scientific Literature | |
13. | ALA4712281 | F | Inhibition of colony formation in human HT-29 cells at 10 to 100 nM incubated for 10 days by crystal violet staining based assay | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature | |
14. | ALA4712283 | F | Antiproliferative activity against human SU-DHL-1 cells incubated for 3 days by WST8 assay | Homo sapiens | 6 | ALA4706631 | cell-based format | Scientific Literature | |
15. | ALA4712284 | B | Protac activity at VHL/MEK1/2 in human NCI-H3122 cells assessed as induction of MEK1/2 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature | |
16. | ALA4712285 | B | Protac activity at VHL/MEK1/2 in human SU-DHL-1 cells assessed as induction of MEK1/2 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature | |
17. | ALA4712286 | B | Inhibition of MEK1/2 phosphorylation in human SU-DHL-1 cells at 0.3 to 3 uM and incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature | |
18. | ALA4712287 | B | Inhibition of MEK1/2 phosphorylation in human NCI-H3122 cells at 0.3 to 3 uM and incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature | |
19. | ALA4712288 | B | Inhibition of ERK phosphorylation in human SU-DHL-1 cells at 0.3 to 3 uM and incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature | |
20. | ALA4712289 | B | Inhibition of ERK phosphorylation in human NCI-H3122 cells at 0.3 to 3 uM and incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature |