# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4724633 | ADME | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 10 uM after 48 hrs by MTT assay relative to control | Homo sapiens | 11 | ALA4715902 | cell-based format | Scientific Literature | |
2. | ALA4724634 | ADME | Metabolic stability in human liver microsomes assessed as half life | Homo sapiens | 11 | ALA4715902 | microsome format | Scientific Literature | |
3. | ALA4724635 | ADME | Metabolic stability in mouse liver microsomes assessed as half life | Mus musculus | 11 | ALA4715902 | microsome format | Scientific Literature | |
4. | ALA4724636 | ADME | Inhibition of CYP3A4 (unknown origin) assessed as formation of 1'-hydroxymidazolam at 10 uM using midazolam as substrate relative to control | Homo sapiens | 11 | ALA4715902 | single protein format | Scientific Literature | |
5. | ALA4724637 | ADME | Inhibition of CYP2D6 (unknown origin) assessed as formation of 4'-hydroxybufuralol at 10 uM using bufuralol as substrate relative to control | Homo sapiens | 11 | ALA4715902 | single protein format | Scientific Literature | |
6. | ALA4724638 | ADME | Inhibition of CYP2C9 (unknown origin) assessed as formation of hydroxytolbutamide at 10 uM using tolbutamide as substrate relative to control | Homo sapiens | 11 | ALA4715902 | single protein format | Scientific Literature | |
7. | ALA4724639 | ADME | Brain concentration in C57BL/6J mouse at 10 mg/kg, po measured after 1 hr by LC-MS/MS analysis | Mus musculus | 1 | ALA4715902 | organism-based format | Scientific Literature | |
8. | ALA4724640 | ADME | Plasma concentration in C57BL/6J mouse at 10 mg/kg, po measured after 1 hr by LC-MS/MS analysis | Mus musculus | 1 | ALA4715902 | organism-based format | Scientific Literature | |
9. | ALA4724641 | Binding | Inhibition of JNK3 in rat primary neuron assessed as reduction in phosphorylation of APP at T688 residue at < 10 nM incubated for 30 mins by Western blot analysis | Rattus norvegicus | 3 | ALA4715902 | tissue-based format | Scientific Literature | |
10. | ALA4724643 | Binding | Inhibition of full-length human JNK3 at 5 uM relative to control | Homo sapiens | 2 | ALA4715902 | single protein format | Scientific Literature | |
11. | ALA4724644 | ADME | Inhibition of CYP1A2 (unknown origin) assessed as formation of acetaminophen at 10 uM using phenaceten as substrate relative to control | Homo sapiens | 11 | ALA4715902 | single protein format | Scientific Literature | |
12. | ALA4724645 | Binding | Inhibition of P38alpha (unknown origin) | Homo sapiens | 24 | ALA4715902 | single protein format | Scientific Literature | |
13. | ALA4724646 | Binding | Selectivity index, ratio of IC50 for JNK2 (unknown origin) to IC50 for JNK3alpha1 (unknown origin) | Homo sapiens | 11 | ALA4715902 | assay format | Scientific Literature | |
14. | ALA4724647 | Binding | Inhibition of JNK2 (unknown origin) using ATF2 as substrate after 22 mins in presence of ATP by HTRF assay | Homo sapiens | 19 | ALA4715902 | single protein format | Scientific Literature | |
15. | ALA4724648 | Binding | Selectivity index, ratio of IC50 for JNK1 (unknown origin) to IC50 for JNK3alpha1 (unknown origin) | Homo sapiens | 23 | ALA4715902 | assay format | Scientific Literature | |
16. | ALA4724649 | Binding | Inhibition of JNK1 (unknown origin) using ATF2 as substrate after 22 mins in presence of ATP by HTRF assay | Homo sapiens | 26 | ALA4715902 | single protein format | Scientific Literature | |
17. | ALA4724650 | Binding | Inhibition of JNK3alpha1 (unknown origin) using ATF2 as substrate after 22 mins in presence of ATP by HTRF assay | Homo sapiens | 26 | ALA4715902 | single protein format | Scientific Literature | |
18. | ALA4840117 | Binding | Inhibition of JNK3alpha1 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysis | Homo sapiens | 31 | ALA4837263 | single protein format | Scientific Literature | |
19. | ALA4840118 | Binding | Inhibition of JNK1 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysis | Homo sapiens | 29 | ALA4837263 | single protein format | Scientific Literature | |
20. | ALA4840119 | Binding | Inhibition of JNK2 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysis | Homo sapiens | 29 | ALA4837263 | single protein format | Scientific Literature |