# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4677825 | ADME | Cytotoxicity against human NCM460 cells harboring low MCT1 expression incubated for 72 hrs by MTT assay | Homo sapiens | 24 | ALA4673309 | cell-based format | Scientific Literature | |
2. | ALA4677826 | Functional | Cytotoxicity against human HCT-116 cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 24 | ALA4673309 | cell-based format | Scientific Literature | |
3. | ALA4677827 | Functional | Cytotoxicity against human HeLa cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 24 | ALA4673309 | cell-based format | Scientific Literature | |
4. | ALA4677828 | Functional | Antiproliferative activity against human HeLa cells assessed as reduction in cell proliferation at IC50 incubated for 6 days and measured on day 6 by MTS assay | Homo sapiens | 2 | ALA4673309 | cell-based format | Scientific Literature | |
5. | ALA4677829 | Functional | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation at IC50 incubated for 6 days and measured on day 6 by MTS assay | Homo sapiens | 2 | ALA4673309 | cell-based format | Scientific Literature | |
6. | ALA4677830 | Functional | Induction of apoptosis in human HeLa cells assessed as early apoptosis measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 2.94 %) | Homo sapiens | 3 | ALA4673309 | cell-based format | Scientific Literature | |
7. | ALA4677831 | Functional | Induction of apoptosis in human HeLa cells assessed as late apoptotic cells measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 3.85 %) | Homo sapiens | 3 | ALA4673309 | cell-based format | Scientific Literature | |
8. | ALA4677832 | Functional | Induction of apoptosis in human HCT-116 cells assessed as early apoptosis measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 3.42 %) | Homo sapiens | 3 | ALA4673309 | cell-based format | Scientific Literature | |
9. | ALA4677833 | Functional | Induction of apoptosis in human HCT-116 cells assessed as late apoptotic cells measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 2.78 %) | Homo sapiens | 3 | ALA4673309 | cell-based format | Scientific Literature | |
10. | ALA4677834 | Functional | Downregulation of MCT1 expression in human HeLa cells at 0.01 to 100 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4673309 | cell-based format | Scientific Literature | |
11. | ALA4677835 | Functional | Downregulation of MCT1 expression in human HCT-116 cells at 0.01 to 100 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4673309 | cell-based format | Scientific Literature | |
12. | ALA4677836 | Functional | Decrease in glucose consumption in human HeLa cells at IC50 after 12 hrs by glucose oxidase based colorimetric assay | Homo sapiens | 1 | ALA4673309 | cell-based format | Scientific Literature | |
13. | ALA4677837 | Functional | Reduction of lactate production in human HeLa cells at IC50 after 8 hrs by colorimetric assay | Homo sapiens | 3 | ALA4673309 | cell-based format | Scientific Literature | |
14. | ALA4677838 | Functional | Decrease in glucose consumption in human HCT-116 cells at IC50 after 4 to 24 hrs by glucose oxidase based colorimetric assay | Homo sapiens | 3 | ALA4673309 | cell-based format | Scientific Literature | |
15. | ALA4677839 | Functional | Reduction of lactate production in human HCT-116 cells at IC50 after 4 to 24 hrs by colorimetric assay | Homo sapiens | 3 | ALA4673309 | cell-based format | Scientific Literature | |
16. | ALA4677840 | Functional | Decrease in intracellular glucose level in human HeLa cells at IC50 after 24 hrs by colorimetric assay | Homo sapiens | 1 | ALA4673309 | cell-based format | Scientific Literature | |
17. | ALA4677842 | Functional | Decrease in intracellular glucose level in human HCT-116 cells at IC50 after 24 hrs by colorimetric assay | Homo sapiens | 1 | ALA4673309 | cell-based format | Scientific Literature | |
18. | ALA4677843 | Functional | Decrease in intracellular glucose level in human HCT-116 cells at IC50 after 4 hrs by colorimetric assay | Homo sapiens | 1 | ALA4673309 | cell-based format | Scientific Literature | |
19. | ALA4677844 | Functional | Inhibition of lactate transport in human HeLa cells assessed as increase in intracellular lactate level at IC50 measured after 8 to 24 hrs by colorimetric assay | Homo sapiens | 3 | ALA4673309 | cell-based format | Scientific Literature | |
20. | ALA4677845 | Functional | Inhibition of lactate transport in human HCT-116 cells assessed as increase in intracellular lactate level at IC50 measured after 8 hrs by colorimetric assay | Homo sapiens | 1 | ALA4673309 | cell-based format | Scientific Literature |