# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4671065 | B | Displacement of [3H]-Diltiazem from L-type calcium channel benzothiazepine binding site in rat brain at 10 uM incubated for 180 mins by scintillation counting analysis relative to control | Rattus norvegicus | 2 | ALA4665820 | tissue-based format | Scientific Literature | |
2. | ALA4671066 | B | Displacement of [3H]-DPCPX from human recombinant adenosine A1 receptor at 10 uM after 60 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
3. | ALA4671067 | B | Displacement of [3H]-CGS 21680 from human recombinant adenosine A2A receptor at 10 uM after 120 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
4. | ALA4671068 | F | Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium mobilization preincubated for 140 secs and treated with EC20 L-AP4 for 125 secs and followed by subsequent addition of EC80 L-AP4 by Fluo-4-AM dye based fluorescence assay | Rattus norvegicus | 27 | ALA4665820 | cell-based format | Scientific Literature | |
5. | ALA4671069 | B | Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux incubated for 140 sec by FluoZin2-AM dye based fluorescence analysis | Rattus norvegicus | 5 | ALA4665820 | cell-based format | Scientific Literature | |
6. | ALA4671072 | A | Plasma clearance in Sprague-Dawley rat at 0.2 to 0.25 mg/kg, iv measured upto 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4665820 | organism-based format | Scientific Literature | |
7. | ALA4671073 | A | Half-life in Sprague-Dawley rat at 0.2 to 0.25 mg/kg, iv measured upto 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4665820 | organism-based format | Scientific Literature | |
8. | ALA4671074 | A | Volume of distribution at steady state in Sprague-Dawley rat at 0.2 to 0.25 mg/kg, iv measured upto 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4665820 | organism-based format | Scientific Literature | |
9. | ALA4671075 | F | Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium mobilization preincubated for 140 secs and treated with EC20 L-AP4 for 125 secs and followed by subsequent addition of EC80 L-AP4 by Fluo-4-AM dye based fluorescence assay relative to maximal induction of L-AP4 | Rattus norvegicus | 27 | ALA4665820 | cell-based format | Scientific Literature | |
10. | ALA4671076 | B | Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux incubated for 140 sec by FluoZin2-AM dye based fluorescence analysis relative to maximal induction of L-AP4 | Rattus norvegicus | 5 | ALA4665820 | cell-based format | Scientific Literature | |
11. | ALA4671077 | B | Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor at 10 uM after 120 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
12. | ALA4671078 | B | Displacement of [3H]-Prazosin from human recombinant adrenergic alpha 1A receptor at 10 uM incubated for 60 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
13. | ALA4671079 | B | Displacement of [3H]-Prazosin from human recombinant adrenergic alpha 1B receptor at 10 uM incubated for 60 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
14. | ALA4671080 | B | Displacement of [3H]-Prazosin from human recombinant adrenergic alpha 1D receptor at 10 uM incubated for 60 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
15. | ALA4671081 | B | Displacement of [3H]-RX821002 from human recombinant adrenergic alpha 2A receptor at 10 uM incubated for 60 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
16. | ALA4671082 | B | Displacement of [3H](-)CGP 12177 from human beta1 adrenoceptor at 10 uM after 60 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
17. | ALA4671083 | B | Displacement of [3H]-(-)CGP 12177 from human recombinant adrenergic beta 2 receptor at 10 uM incubated for 120 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
18. | ALA4671084 | B | Displacement of [3H]-methyltrienolone from human androgen receptor at 10 uM incubated for 1440 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
19. | ALA4671085 | B | Displacement of [3H]desArg10-KD from human recombinant Bradykinin B1 receptor at 10 uM incubated for 120 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature | |
20. | ALA4671086 | B | Displacement of [3H]bradykinin from human recombinant B2 receptor at 10 uM after 60 mins by scintillation counting analysis relative to control | Homo sapiens | 2 | ALA4665820 | single protein format | Scientific Literature |