| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4676459 | B | Binding affinity to human plasma coagulation factor XIIA assessed as compound-adduct formation at molar ratio of 1:20 preincubated for 4 mins followed by desalination and measured after 120 mins by SEC/ESI-TOF mass spectra analysis | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 2. | ALA4676460 | B | Binding affinity to human plasma coagulation factor XIIA assessed as compound-adduct formation at molar ratio of 1:20 preincubated for 4 mins followed by desalination and measured after 5 mins by SEC/ESI-TOF mass spectra analysis | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 3. | ALA4676461 | B | Binding affinity to human plasma coagulation factor XIIA assessed as compound-adduct formation by measuring change in molecular mass at molar ratio of 1:20 measured after 4 mins by SEC/ESI-TOF mass spectra analysis | Homo sapiens | 3 | ALA4673255 | cell-free format | Scientific Literature | |
| 4. | ALA4676462 | F | Anticoagulant activity in human platelet-rich plasma assessed as reduction in TF-induced thrombin generation by measuring endogenous thrombin potential at 100 uM preincubated for 15 mins followed by TF addition by Z-Gly-Gly-Arg-AMC substrate based calibrated automated thrombography (Rvb = 1203 +/- 44 AU.min/L) | Homo sapiens | 3 | ALA4673255 | cell-free format | Scientific Literature | |
| 5. | ALA4676463 | F | Anticoagulant activity in human platelet-rich plasma assessed as reduction in TF-induced thrombin generation by measuring Tmax of clotting time at 100 uM preincubated for 15 mins followed by TF addition by Z-Gly-Gly-Arg-AMC substrate based calibrated automated thrombography (Rvb = 8.1 +/- 0.6 min) | Homo sapiens | 3 | ALA4673255 | cell-free format | Scientific Literature | |
| 6. | ALA4676464 | F | Anticoagulant activity in human platelet-rich plasma assessed as reduction in TF-induced thrombin generation by measuring half life of clotting time at 100 uM preincubated for 15 mins followed by TF addition by Z-Gly-Gly-Arg-AMC substrate based calibrated automated thrombography (Rvb= 3 +/- 0.5 min) | Homo sapiens | 3 | ALA4673255 | cell-free format | Scientific Literature | |
| 7. | ALA4676465 | F | Anticoagulant activity in human platelet-rich plasma assessed as reduction in TF-induced thrombin generation by measuring amplitude of thrombin peak at 100 uM preincubated for 15 mins followed by TF addition by Z-Gly-Gly-Arg-AMC substrate based calibrated automated thrombography (Rvb = 63 +/- 3.7 AU/L) | Homo sapiens | 3 | ALA4673255 | cell-free format | Scientific Literature | |
| 8. | ALA4676466 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of TRAP6 induced platelet activation by measuring reduction in ATP release at 10 uM preincubated for 20 mins followed by TRAP6 addition and measured after 10 mins by luciferin-based luminescence assay | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 9. | ALA4676467 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of TRAP6 induced platelet activation by measuring reduction in ATP release at 1 uM preincubated for 20 mins followed by TRAP6 addition and measured after 10 mins by luciferin-based luminescence assay | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 10. | ALA4676468 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of thrombin induced platelet activation by measuring reduction in ATP release preincubated for 20 mins followed by thrombin addition and measured after 10 mins by luciferin-based luminescence assay | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 11. | ALA4676469 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of MDA-MB-231 induced platelet activation by measuring reduction in ATP release preincubated for 20 mins followed by tumor cell addition and measured after 30 mins by luciferin-based luminescence assay | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 12. | ALA4676470 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of TRAP6-induced platelet aggregation at 0.1 to 10 uM by light transmission aggregometry | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 13. | ALA4676471 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of thrombin-induced platelet aggregation at 1 to 10 uM by light transmission aggregometry | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 14. | ALA4676472 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of MDA-MB-231-induced platelet aggregation at 10 uM by light transmission aggregometry | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 15. | ALA4676473 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of MDA-MB-231-induced platelet aggregation at 1 uM by light transmission aggregometry | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 16. | ALA4676474 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of MDA-MB-231-induced platelet aggregation at 100 nM by light transmission aggregometry | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 17. | ALA4676475 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of MDA-MB-231-induced platelet aggregation by light transmission aggregometry | Homo sapiens | 1 | ALA4673255 | cell-free format | Scientific Literature | |
| 18. | ALA4676479 | F | Anticoagulant activity in human blood assessed as concentration required to double the activated partial thromboplastin time incubated for 1 min followed by aPTT reagent based assay | Homo sapiens | 2 | ALA4673255 | tissue-based format | Scientific Literature | |
| 19. | ALA4676483 | B | Inhibition of human coagulation factor Xa using Boc-Ile-Glu-Gly-Arg-AMC as fluorogenic substrate at 5 uM measured at 1 min interval for 1 hr by fluorometric assay relative to control | Homo sapiens | 1 | ALA4673255 | single protein format | Scientific Literature | |
| 20. | ALA4676486 | B | Inhibition of human coagulation factor XIA using Mes-dArg-Pro-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assay | Homo sapiens | 5 | ALA4673255 | single protein format | Scientific Literature |
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