The store will not work correctly when cookies are disabled.
The page will load shortly, Thanks for your patience!
| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source |
| 1. | ALA4727478 | Functional | In vivo antagonist activity at TLR9 in 129Sv mouse assessed as inhibition of CpG1585-induced IL6 release at 30 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA4725311 | organism-based format | Scientific Literature |
| 2. | ALA4727479 | Functional | In vivo antagonist activity at TLR9 in 129Sv mouse assessed as inhibition of CpG1585-induced IFNalpha release at 30 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA4725311 | organism-based format | Scientific Literature |
| 3. | ALA4727480 | Functional | In vivo antagonist activity at TLR7 in 129Sv mouse assessed as inhibition of ssRNAR0006-induced IL6 release at 30 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA4725311 | organism-based format | Scientific Literature |
| 4. | ALA4727481 | Functional | In vivo antagonist activity at TLR7 in 129Sv mouse assessed as inhibition of ssRNAR0006-induced IFNalpha release at 30 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA4725311 | organism-based format | Scientific Literature |
| 5. | ALA4727484 | Binding | Antagonist activity at TLR7 in mouse splenocytes assessed as inhibition of ssRNA40-induced IL6 production | Mus musculus | 12 | ALA4725311 | cell-based format | Scientific Literature |
| 6. | ALA4727485 | Binding | Antagonist activity at TLR9 in mouse splenocytes assessed as inhibition of CpG1585-induced IL6 production | Mus musculus | 13 | ALA4725311 | cell-based format | Scientific Literature |
| 7. | ALA4727486 | Binding | Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha production | Homo sapiens | 15 | ALA4725311 | tissue-based format | Scientific Literature |
| 8. | ALA4727488 | Binding | Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Homo sapiens | 14 | ALA4725311 | cell-based format | Scientific Literature |
| 9. | ALA4727489 | Binding | Antagonist activity at TLR9 in human PBMC assessed as inhibition of ODN2216-induced IFNalpha production | Homo sapiens | 13 | ALA4725311 | tissue-based format | Scientific Literature |
| 10. | ALA4727492 | ADME | AUC in BALB/c mouse at 20 mg/kg, po | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature |
| 11. | ALA4727493 | ADME | Cmax in BALB/c mouse at 20 mg/kg, po | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature |
| 12. | ALA4727494 | ADME | Clearance in BALB/c mouse at 5 mg/kg, iv | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature |
| 13. | ALA4727495 | ADME | Volume of distribution at steady state in BALB/c mouse at 5 mg/kg, iv | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature |
| 14. | ALA4727496 | ADME | Terminal half life in BALB/c mouse at 5 mg/kg, iv | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature |
| 15. | ALA4727497 | ADME | Oral bioavailability in BALB/c mouse at 20 mg/kg | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature |
| 16. | ALA4727501 | ADME | Drug uptake in 129Sv mouse at 30 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA4725311 | organism-based format | Scientific Literature |