| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4667925 | U | Ratio of IC50 for antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay to Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs post-dosing on day 4 by LC/MS analysis | 3 | organism-based format | Scientific Literature | |||
| 2. | ALA4667934 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs post-dosing on day 4 by LC/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 3. | ALA4667935 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 6 hrs post-dosing on day 4 by LC/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 4. | ALA4667936 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 1 hr post-dosing on day 4 by LC/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 5. | ALA4667940 | A | Apparent volume of distribution in KM mouse at 2 mg/kg, iv administered as cassette dosing measured up to 24 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA4667941 | A | Half life in KM mouse at 2 mg/kg, iv administered as cassette dosing measured up to 24 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA4667942 | A | Inhibition of recombinant human CYP2C19 expressed in baculovirus infected insect cells using s-mephenytoin as substrate incubated for 30 mins in presence of NADPH-regenerating system by fluorescence based assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4667943 | A | Apparent clearance in KM mouse at 2 mg/kg, iv administered as cassette dosing measured up to 24 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA4667944 | A | Inhibition of recombinant human CYP2C9 expressed in baculovirus infected insect cells using tolbutamide as substrate incubated for 30 mins in presence of NADPH-regenerating system by fluorescence based assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4667945 | A | Inhibition of recombinant human CYP2D6 expressed in baculovirus infected insect cells using dextromethorphan as substrate incubated for 30 mins in presence of NADPH-regenerating system by fluorescence based assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4667946 | A | Inhibition of recombinant human CYP1A2 expressed in baculovirus infected insect cells using phenacetin as substrate incubated for 30 mins in presence of NADPH-regenerating system by fluorescence based assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4667947 | A | Inhibition of recombinant human CYP3A4 expressed in baculovirus infected insect cells using midazolam as substrate incubated for 30 mins in presence of NADPH-regenerating system by fluorescence based assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4667948 | T | Selectivity ratio of IC50 for human ERG incubated for 2 hrs by fluorescence polarization assay to IC50 for CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay | 3 | assay format | Scientific Literature | |||
| 14. | ALA4667949 | B | Inhibition of recombinant human BACE1 using Mca-SEVNLDAEFRK(Dnp)RR-NH2 fluorogenic peptide as substrate incubated for 60 mis by fluorescence based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 15. | ALA4667950 | B | Displacement of Tracer Red from human ERG incubated for 2 hrs by fluorescence polarization assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 16. | ALA4667951 | B | Inhibition of Plasmodium falciparum plasmepsin 4 using PM-2 peptide substrate incubated for 60 mis by fluorescence based assay | Plasmodium falciparum | 3 | assay format | Scientific Literature | ||
| 17. | ALA4667952 | B | Inhibition of Plasmodium falciparum plasmepsin 2 using PM-2 peptide substrate incubated for 60 mis by fluorescence based assay | Plasmodium falciparum | 3 | single protein format | Scientific Literature | ||
| 18. | ALA4667953 | F | Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay | Plasmodium falciparum | 38 | organism-based format | Scientific Literature | ||
| 19. | ALA4667954 | F | Antimalarial activity against multidrug resistant Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay | Plasmodium falciparum | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4667955 | F | Antimalarial activity against Plasmodium chabaudi ASS infected in NIH mouse assessed as inhibition of parasitemia at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs after last-drug treatment by Peter's 4-day suppressive test relative to control | Plasmodium chabaudi | 4 | organism-based format | Scientific Literature |
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