# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4672629 | B | Inhibition of 6xHis-tagged human recombinant PDE4D3 expressed in Sf9 cells by scintillation counting method | Homo sapiens | 3 | ALA4665888 | cell-based format | Scientific Literature | |
2. | ALA4672630 | B | Inhibition of 6xHis-tagged human recombinant PDE1B1 expressed in HEK cells by scintillation counting method | Homo sapiens | 3 | ALA4665888 | cell-based format | Scientific Literature | |
3. | ALA4672632 | B | Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation counting method | Homo sapiens | 44 | ALA4665888 | cell-based format | Scientific Literature | |
4. | ALA4672633 | B | Inhibition of 6xHis-tagged human recombinant PDE3A expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation counting method | Homo sapiens | 36 | ALA4665888 | cell-based format | Scientific Literature | |
5. | ALA4672634 | B | Inhibition of 6xHis-tagged rat recombinant PDE10A2 expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation counting method | Rattus norvegicus | 38 | ALA4665888 | cell-based format | Scientific Literature | |
6. | ALA4672636 | B | Inhibition of 6xHis-tagged human recombinant PDE5A3 expressed in Sf9 cells by scintillation counting method | Homo sapiens | 3 | ALA4665888 | cell-based format | Scientific Literature | |
7. | ALA4672637 | B | Inhibition of 6xHis-tagged human recombinant PDE7A1 expressed in Sf9 cells by scintillation counting method | Homo sapiens | 3 | ALA4665888 | cell-based format | Scientific Literature | |
8. | ALA4672639 | B | Inhibition of 6xHis-tagged human recombinant PDE11A4 expressed in HEK cells by scintillation counting method | Homo sapiens | 3 | ALA4665888 | cell-based format | Scientific Literature | |
9. | ALA4672643 | P | Solubility in pH 7.4 buffer | 8 | ALA4665888 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4672644 | A | Inhibition of CYP3A4 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
11. | ALA4672646 | A | Inhibition of CYP2C9 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
12. | ALA4672647 | A | Inhibition of CYP2C19 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
13. | ALA4672648 | A | Inhibition of CYP2D6 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
14. | ALA4672649 | A | Inhibition of CYP1A2 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
15. | ALA4672656 | A | Intrinsic clearance in rat liver microsomes at 1 uM incubated for 60 mins | Rattus norvegicus | 8 | ALA4665888 | microsome format | Scientific Literature | |
16. | ALA4672657 | A | Intrinsic clearance in human liver microsomes at 1 uM incubated for 60 mins | Homo sapiens | 8 | ALA4665888 | microsome format | Scientific Literature | |
17. | ALA4672658 | A | Half life in rat liver microsomes at 1 uM | Rattus norvegicus | 8 | ALA4665888 | microsome format | Scientific Literature | |
18. | ALA4672659 | A | Half life in human liver microsomes at 1 uM | Homo sapiens | 8 | ALA4665888 | microsome format | Scientific Literature | |
19. | ALA4672660 | A | Plasma concentration in Sprague-Dawley rat at 10 mg/kg, sc | Rattus norvegicus | 2 | ALA4665888 | organism-based format | Scientific Literature | |
20. | ALA4672662 | A | Drug concentration in Sprague-Dawley rat brain at 10 mg/kg, sc | Rattus norvegicus | 2 | ALA4665888 | organism-based format | Scientific Literature |