# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4736771 | Binding | Binding affinity to FKBP12 (unknown origin) expressed in HEK293 cells co-expressing FRB assessed as induction of FKBP12-FRB dimerization at 10 mM measured for 15 mins by nano-glo live cell reagent based luminescence assay | Homo sapiens | 1 | ALA4732161 | cell-based format | Scientific Literature | |
2. | ALA4736772 | Binding | Binding affinity to FKBP12 (unknown origin) expressed in HEK293 cells co-expressing FRB assessed as inhibition of rapamycin-induced FKBP12-FRB dimerization measured after 25 mins by nano-glo live cell reagent based luminescence assay | Homo sapiens | 2 | ALA4732161 | cell-based format | Scientific Literature | |
3. | ALA4736773 | Binding | Binding affinity to FKBP12 (unknown origin) expressed in HEK293 cells co-expressing FRB assessed as inhibition of rapamycin-induced FKBP12-FRB dimerization at 3 mM measured after 25 mins by nano-glo live cell reagent based luminescence assay relative to control | Homo sapiens | 17 | ALA4732161 | cell-based format | Scientific Literature | |
4. | ALA4736775 | Binding | Stabilization of FKBP12/RyR1 protein-protein interaction in human myotubes assessed as reversal of SIN1-induced reduction in FKBP12/RyR1 co-localization at 150 nM by in situ proximity ligation assay relative to control | Homo sapiens | 2 | ALA4732161 | tissue-based format | Scientific Literature | |
5. | ALA4736776 | Binding | Effect on FKBP12/RyR1 protein-protein interaction in human myotubes by in situ proximity ligation assay | Homo sapiens | 2 | ALA4732161 | tissue-based format | Scientific Literature | |
6. | ALA4736777 | Binding | Stabilization of FKBP12/RyR1 protein-protein interaction in human 8220 myoblast-derived myotubes assessed as reversal of SIN1-induced intracellular calcium leakage at 150 nM preincubated for 12 hrs followed by SIN1 stimulation and measured after 6 hrs by fura-2 AM dye based fluorescence assay relative to control | Homo sapiens | 16 | ALA4732161 | tissue-based format | Scientific Literature |