| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4713702 | F | Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 3 days by MTT assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 2. | ALA4713703 | F | Antiproliferative activity against human BxPC-3 cells assessed as reduction in cell viability incubated for 3 days by MTT assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 3. | ALA4713704 | F | Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 3 days by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4713705 | F | Selectivity index, ratio of IC50 for antiproliferative activity against STAT3 knockout human OVCAR-3 cells to IC50 for wild type human OVCAR-3 cells | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 5. | ALA4713706 | B | Protac activity at CRBN/STAT3 in human OVCAR-3 cells assessed as depletion of STAT3 at 2 to 20 uM after 12 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4713707 | B | Protac activity at CRBN/STAT3 in human OVCAR-3 cells assessed as decrease in STAT3 phosphorylation at 2 to 20 uM after 6 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4713708 | B | Protac activity at CRBN/STAT3 in human OVCAR-3 cells assessed as decrease in STAT3 expression at 2 to 10 uM incubated for 24 hrs in presence of proteasome inhibitor MG132 by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4713709 | B | Protac activity at CRBN/STAT3 in human OVCAR-3 cells assessed as induction of STAT3 degradation at 1 to 20 uM incubated for 12 hrs in presence of competitive CRBN ligand pomalidomide by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4713710 | B | Protac activity at CRBN/STAT1 in human OVCAR-3 cells assessed as decrease in STAT1 expression levels at 2 to 20 uM after 12 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4713711 | B | Protac activity at CRBN/STAT3 in human BxPC-3 cells assessed as decrease in STAT3 expression level after 12 hrs by western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4713712 | B | Protac activity at CRBN/STAT3 in human BxPC-3 cells assessed as induction of STAT3 degradation at 1 to 5 uM after 12 hrs in presence of proteasome inhibitor bortezomib by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4713714 | F | Reduction in NQO1 levels in human BxPC-3 cells at 1 to 10 uM incubated for 16 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4713716 | B | Protac activity at CRBN/STAT3 in human BxPC-3 cells assessed as effect on GSPT1 protein expression level at 1 to 10 uM incubated for 16 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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