# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4727603 | Binding | Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]-methyl-alpha -D-glucopyranoside accumulation | Homo sapiens | 12 | ALA4725317 | cell-based format | Scientific Literature | |
2. | ALA4727604 | Binding | Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]-methyl-alpha -D-glucopyranoside accumulation | Homo sapiens | 12 | ALA4725317 | cell-based format | Scientific Literature | |
3. | ALA4727607 | ADME | Stability of compound in human liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH | Homo sapiens | 11 | ALA4725317 | microsome format | Scientific Literature | |
4. | ALA4727609 | ADME | Stability of compound in mouse liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH | Mus musculus | 11 | ALA4725317 | microsome format | Scientific Literature | |
5. | ALA4727610 | ADME | Stability of compound in rat liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH | Rattus norvegicus | 11 | ALA4725317 | microsome format | Scientific Literature | |
6. | ALA4727611 | ADME | Clearance in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po | Rattus norvegicus | 4 | ALA4725317 | organism-based format | Scientific Literature | |
7. | ALA4727612 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po | Rattus norvegicus | 4 | ALA4725317 | organism-based format | Scientific Literature | |
8. | ALA4727613 | ADME | Half life in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 4 | ALA4725317 | organism-based format | Scientific Literature | |
9. | ALA4727615 | ADME | Cmax in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po | Rattus norvegicus | 4 | ALA4725317 | organism-based format | Scientific Literature | |
10. | ALA4727616 | ADME | Tmax in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po | Rattus norvegicus | 4 | ALA4725317 | organism-based format | Scientific Literature | |
11. | ALA4727617 | ADME | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 4 | ALA4725317 | organism-based format | Scientific Literature |