| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4701888 | Functional | Antiproliferative activity against human KYSE-520 cells | Homo sapiens | 20 | ALA4699491 | cell-based format | Scientific Literature | |
| 2. | ALA4701889 | Binding | Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY122 incubated for 30 mins by fluorescence based DIFMUP assay | Homo sapiens | 29 | ALA4699491 | assay format | Scientific Literature | |
| 3. | ALA4701891 | Binding | Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assay | Homo sapiens | 20 | ALA4699491 | cell-based format | Scientific Literature | |
| 4. | ALA4701899 | Physicochemical | Aqueous solubility of the compound at pH 6.8 | 18 | ALA4699491 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4701900 | Physicochemical | Lipophilicity, logP of the compound | 18 | ALA4699491 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4701901 | Physicochemical | Distribution coefficient, logD of the compound | 18 | ALA4699491 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4701902 | Binding | Inhibition of human ERG by Q-patch assay | Homo sapiens | 18 | ALA4699491 | single protein format | Scientific Literature | |
| 8. | ALA5226254 | Binding | Allosteric inhibition of IRS1 peptide-activated human recombinant SHP2 (Met1 to Leu525) expressed in Escherichia coli assessed as inhibition of dephosphorylation of 6,8-difluoro-4-methylumbelliferyl phosphate using DiFMUP as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured after 30 mins by DiFMUP assay | Homo sapiens | 23 | ALA5223191 | assay format | Scientific Literature |
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