# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4733567 | Functional | Antiproliferative activity against human HCC827 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 53 | ALA4732067 | cell-based format | Scientific Literature | |
2. | ALA4733568 | Functional | Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 53 | ALA4732067 | cell-based format | Scientific Literature | |
3. | ALA4733569 | Functional | Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 53 | ALA4732067 | cell-based format | Scientific Literature | |
4. | ALA4733570 | Functional | Antiproliferative activity against human A549 cells expressing wild type EGFR assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 6 | ALA4732067 | cell-based format | Scientific Literature | |
5. | ALA4733571 | Functional | Antiproliferative activity against human SPCA1 cells expressing wild type EGFR assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 6 | ALA4732067 | cell-based format | Scientific Literature | |
6. | ALA4733572 | Functional | Antiproliferative activity against human NCI-H1650 cells expressing EGFR mutant assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 6 | ALA4732067 | cell-based format | Scientific Literature | |
7. | ALA4733573 | Functional | Antiproliferative activity against human NCI-H441 cells expressing EGFR mutant assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 6 | ALA4732067 | cell-based format | Scientific Literature | |
8. | ALA4733574 | Physicochemical | Aqueous solubility of the compound by HPLC analysis | 5 | ALA4732067 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4733575 | ADME | Metabolic stability in human liver microsomes assessed as half life | Homo sapiens | 6 | ALA4732067 | microsome format | Scientific Literature | |
10. | ALA4733576 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance per gram protein | Homo sapiens | 6 | ALA4732067 | microsome format | Scientific Literature | |
11. | ALA4733577 | ADME | Cytotoxicity against mouse L929 cells | Mus musculus | 5 | ALA4732067 | cell-based format | Scientific Literature | |
12. | ALA4733578 | ADME | Cytotoxicity against Chinese hamster CHL cells | Cricetulus griseus | 5 | ALA4732067 | cell-based format | Scientific Literature | |
13. | ALA4733579 | ADME | Cytotoxicity against HUVEC | Homo sapiens | 5 | ALA4732067 | cell-based format | Scientific Literature | |
14. | ALA4733580 | ADME | Cytotoxicity against rat H9C2 cells | Rattus norvegicus | 5 | ALA4732067 | cell-based format | Scientific Literature | |
15. | ALA4733581 | Functional | Antitumor activity against mouse C26 cells xenografted in BALB/c mouse assessed as tumor growth inhibition at 50 mg/kg, po administered once daily and measured every two days by caliper method relative to control | Mus musculus | 4 | ALA4732067 | organism-based format | Scientific Literature | |
16. | ALA4733582 | Toxicity | Toxicity in nude BALB/c mouse xenografted with C26 cells assessed as change in body weight at 50 mg/kg, po administered once daily and measured every two days | Mus musculus | 3 | ALA4732067 | organism-based format | Scientific Literature | |
17. | ALA4733583 | Toxicity | Toxicity in nude BALB/c mouse xenografted with C26 cells assessed as abnormalities in liver size and morphology at 50 mg/kg, po administered once daily | Mus musculus | 3 | ALA4732067 | organism-based format | Scientific Literature | |
18. | ALA4733584 | Toxicity | Toxicity in nude BALB/c mouse xenografted with C26 cells assessed as abnormalities in kidney size and morphology at 50 mg/kg, po administered once daily | Mus musculus | 3 | ALA4732067 | organism-based format | Scientific Literature | |
19. | ALA4733585 | Toxicity | Toxicity in nude BALB/c mouse xenografted with C26 cells assessed as abnormalities in lung size and morphology at 50 mg/kg, po administered once daily | Mus musculus | 3 | ALA4732067 | organism-based format | Scientific Literature | |
20. | ALA4733586 | Toxicity | Toxicity in nude BALB/c mouse xenografted with C26 cells assessed as abnormalities in heart size and morphology at 50 mg/kg, po administered once daily | Mus musculus | 3 | ALA4732067 | organism-based format | Scientific Literature |