# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4682703 | Binding | Antagonist activity at PAC1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of PACAP-induced inhibition of CREB phosphorylation at 1 nM preincubated for 30 mins followed by PACAP stimulation and measured after 30 mins by Western blot analysis relative to control | Homo sapiens | 2 | ALA4680128 | cell-based format | Scientific Literature | |
2. | ALA4682704 | Binding | Antagonist activity at PAC1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of PACAP-induced inhibition of CREB phosphorylation preincubated for 30 mins followed by PACAP stimulation and measured after 30 mins by Western blot analysis | Homo sapiens | 2 | ALA4680128 | cell-based format | Scientific Literature | |
3. | ALA4682705 | Functional | Antiallodynic activity in PACAP-induced mechanical allodynia ddy mouse model assessed as increase in ipsilateral paw withdrawal threshold at 100 pmol, it | Mus musculus | 2 | ALA4680128 | organism-based format | Scientific Literature | |
4. | ALA4682706 | Functional | Antiallodynic activity in ddy mouse model of spinal nerve ligation-induced neuropathic pain assessed as reduction in ipsilateral paw withdrawal latency at 100 pmol, it administered as single dose measured up to 24 hrs | Mus musculus | 2 | ALA4680128 | organism-based format | Scientific Literature | |
5. | ALA4682707 | ADME | Effect on nociception on contralateral paw in ddy mouse model of spinal nerve ligation-induced neuropathic pain at 100 pmol, it administered as single dose measured up to 24 hrs | Mus musculus | 2 | ALA4680128 | assay format | Scientific Literature | |
6. | ALA4682708 | Functional | Antiallodynic activity in ddy mouse model of spinal nerve ligation-induced neuropathic pain assessed as reduction in ipsilateral paw withdrawal latency at 30 mg/kg, po administered as single dose measured up to 24 hrs | Mus musculus | 2 | ALA4680128 | organism-based format | Scientific Literature | |
7. | ALA4682709 | ADME | Effect on nociception on contralateral paw in ddy mouse model of spinal nerve ligation-induced neuropathic pain at 30 mg/kg, po administered as single dose measured up to 24 hrs | Mus musculus | 2 | ALA4680128 | organism-based format | Scientific Literature |