# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4704510 | Functional | Antiviral activity against GFP-fused Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | Human adenovirus 5 | 68 | ALA4699598 | organism-based format | Scientific Literature | |
2. | ALA4704511 | ADME | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by alamarBlue assay | Homo sapiens | 68 | ALA4699598 | cell-based format | Scientific Literature | |
3. | ALA4704512 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by alamarBlue assay to IC50 for antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | 68 | ALA4699598 | cell-based format | Scientific Literature | ||
4. | ALA4704513 | Functional | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation at 10 uM incubated for 7 days by GFP reporter gene assay relative to control | Human adenovirus 5 | 66 | ALA4699598 | organism-based format | Scientific Literature | |
5. | ALA4822329 | Functional | Antiviral activity against RSV infected in human A549 cells assessed as reduction in viral titer at 10 uM incubated for 15 hrs by immunostaining analysis | Respiratory syncytial virus | 21 | ALA4819107 | organism-based format | Scientific Literature | |
6. | ALA4822330 | ADME | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 15 hrs by LDH assay | Homo sapiens | 21 | ALA4819107 | cell-based format | Scientific Literature | |
7. | ALA4822331 | Functional | Antiinflammatory activity against in human A549 cells transfected with PRDIII-I-Luc and IRF-3-Luc assessed as reduction in RSV-induced IRF3 activation at 10 uM incubated for 15 hrs by luciferase reporter gene assay | Homo sapiens | 7 | ALA4819107 | cell-based format | Scientific Literature | |
8. | ALA4822332 | Functional | Antiinflammatory activity against in human A549 cells transfected with NF-kappaB-Luc assessed as reduction in RSV-induced NF-kappaB activation at 10 uM incubated for 15 hrs by luciferase reporter gene assay | Homo sapiens | 7 | ALA4819107 | cell-based format | Scientific Literature | |
9. | ALA4822333 | Functional | Antiinflammatory activity against in human A549 cells assessed as reduction in RSV-induced IRF3 mRNA expression at 10 uM incubated for 4 hrs by qRT-PCR analysis | Homo sapiens | 7 | ALA4819107 | cell-based format | Scientific Literature | |
10. | ALA4822334 | Functional | Antiinflammatory activity against in human A549 cells assessed as reduction in RSV-induced NF-kappaB mRNA expression at 10 uM incubated for 4 hrs by qRT-PCR analysis | Homo sapiens | 7 | ALA4819107 | cell-based format | Scientific Literature | |
11. | ALA4822335 | Functional | Antiinflammatory activity against in human SAEC cells assessed as reduction in RSV-induced MIP-1beta production at 10 uM incubated for 4 hrs by immunoassay | Homo sapiens | 3 | ALA4819107 | cell-based format | Scientific Literature |