# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4677162 | Functional | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 6.25 mg/kg, iv administered as bolus dose for 5 consecutive days | Homo sapiens | 5 | ALA4673269 | organism-based format | Scientific Literature | |
2. | ALA4677169 | Functional | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 6.25 mg/kg, iv administered as bolus dose for 5 consecutive days measured on day 2 relative to control | Homo sapiens | 4 | ALA4673269 | organism-based format | Scientific Literature | |
3. | ALA4677176 | Functional | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as tumor growth inhibition at 6.25 mg/kg, iv administered as bolus dose for 5 consecutive days measured on day 7 relative to control | Homo sapiens | 1 | ALA4673269 | organism-based format | Scientific Literature | |
4. | ALA4677187 | Functional | Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 68 | ALA4673269 | cell-based format | Scientific Literature | |
5. | ALA4677188 | Binding | Inhibition of C-terminal TQ5WS-labelled QWAREIGAQLRRMADDLNAQY binding to human C-terminal Cy5-labelled Mcl-1 V321C/C286S mutant (171 to 321 residue) incubated for 2 hrs by fluorescence polarization analysis | Homo sapiens | 68 | ALA4673269 | assay format | Scientific Literature | |
6. | ALA4677189 | Functional | Induction of apoptosis in human AMO1 cells xenografted in CB-17 SCID mouse assessed as increase in cleaved PARP level at 12.5 mg/kg, iv administered as bolus dose measured after 16 hrs by immunodetection analysis relative to control | Homo sapiens | 26 | ALA4673269 | organism-based format | Scientific Literature |