| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4724675 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM pyrophosphate by scintillation proximity assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 2. | ALA4724676 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM phosphate by scintillation proximity assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 3. | ALA4724677 | B | Inhibition of rat recombinant FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM thiosulfate by scintillation proximity assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 4. | ALA4724678 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM ATP by scintillation proximity assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 5. | ALA4724679 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM DMA-PP by scintillation proximity assay | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 6. | ALA4724680 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 2 mM DMA-PP by scintillation proximity assay | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 7. | ALA4724681 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 1 mM DMA-PP by scintillation proximity assay | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 8. | ALA4724682 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins by scintillation proximity assay | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 9. | ALA4724683 | B | Binding affinity to recombinant FTase (unknown origin) assessed as change in melting temperature at 20 uM by TdF assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 10. | ALA4724684 | B | Binding affinity to recombinant FTase (unknown origin) assessed as melting temperature at 20 uM by TdF assay (Rvb = 46.2 +/- 0.2 degreeC) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4724685 | B | Displacement of (1-(2-aminoethyl)-3,5-dimethyl-1H-pyrazol-4-yl)(4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone from AFG3L2 in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA4724686 | B | Displacement of (1-(2-aminoethyl)-3,5-dimethyl-1H-pyrazol-4-yl)(4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone from NMRAL1 in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA4724687 | B | Displacement of (1-(2-aminoethyl)-3,5-dimethyl-1H-pyrazol-4-yl)(4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone from FNTB in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4724688 | B | Displacement of (1-(2-aminoethyl)-3,5-dimethyl-1H-pyrazol-4-yl)(4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone from FNTA in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA4724689 | F | Potentiation of vorinostat-induced reactivation of latent HIV-1 infected in human Jurkat 2C4 cells assessed as increase in HIV-1 transcription incubated for 24 hrs in presence of vorinostat by Steady-Glo luciferase reporter gene assay relative to control | Human immunodeficiency virus 1 | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA4724690 | F | Reactivation of latent HIV-1 infected in human Jurkat 2C4 cells assessed as increase in HIV-1 transcription incubated for 24 hrs by Steady-Glo luciferase reporter gene assay | Human immunodeficiency virus 1 | 4 | organism-based format | Scientific Literature | ||
| 17. | ALA4724691 | F | Potentiation of vorinostat-induced reactivation of latent HIV-1 infected in human Jurkat 2C4 cells assessed as increase in HIV-1 transcription incubated for 24 hrs in presence of vorinostat by Steady-Glo luciferase reporter gene assay | Human immunodeficiency virus 1 | 4 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!