# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4677164 | F | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 25 mg/kg, iv administered as bolus dose for 5 consecutive days | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
2. | ALA4677165 | F | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 50 mg/kg, iv administered as bolus dose for 5 consecutive days | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
3. | ALA4677172 | F | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 25 mg/kg, iv administered as bolus dose for 5 consecutive days measured on day 4 relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
4. | ALA4677173 | F | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 50 mg/kg, iv administered as bolus dose for 5 consecutive days measured on day 2 relative to control | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
5. | ALA4677178 | F | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as tumor growth inhibition at 50 mg/kg, iv for 5 days measured on day 7 relative to control | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
6. | ALA4677179 | F | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as tumor growth inhibition at 25 mg/kg, iv for 5 days measured on day7 relative to control | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
7. | ALA4677180 | F | Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as tumor growth inhibition administered intravenously for 5 days measured post-last dose | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4677181 | F | Induction of apoptosis in human AMO1 cells xenografted in CB-17 SCID mouse assessed as increase in cleaved PARP level at 25 to 50 mg/kg, iv administered as bolus dose measured after 30 hrs by immunodetection analysis | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
9. | ALA4677182 | F | Induction of apoptosis in human AMO1 cells xenografted in CB-17 SCID mouse assessed as increase in cleaved PARP level administered intravenously as bolus dose measured after 6 to 16 hrs by immunodetection analysis | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
10. | ALA4677183 | F | Induction of apoptosis in human AMO1 cells xenografted in CB-17 SCID mouse assessed as increase in cleaved PARP level at 25 to 50 mg/kg, iv administered as bolus dose measured after 6 hrs by immunodetection analysis | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
11. | ALA4677187 | F | Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 68 | cell-based format | Scientific Literature | ||
12. | ALA4677188 | B | Inhibition of C-terminal TQ5WS-labelled QWAREIGAQLRRMADDLNAQY binding to human C-terminal Cy5-labelled Mcl-1 V321C/C286S mutant (171 to 321 residue) incubated for 2 hrs by fluorescence polarization analysis | Homo sapiens | 68 | assay format | Scientific Literature |