| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4679878 | B | Inhibition of HPGDS in human KU812 cells assessed as reduction in PGD2 level at 10 to 100 nM incubated for 24 hrs followed by A23187 treatment and measured after 30 mins and subsequent compound washout then further incubated for 6 hrs in compound-free medium by ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4679879 | P | Solubility of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4679880 | A | Permeability of the compound | 2 | assay format | Scientific Literature | |||
| 4. | ALA4679881 | B | Inhibition of HPGDS in human KU812 cells assessed as reduction in PGD2 level at 10 to 100 nM incubated for 24 hrs followed by A23187 treatment and measured after 30 mins by ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4679883 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as induction of HPGDS degradation at 10 to 100 nM incubated for 24 hrs followed by compound washout and further incubated for 6 hrs in compound-free medium by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4679884 | B | Inhibition of recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 3 mins by spectrophotometric analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 7. | ALA4679885 | B | Binding affinity to recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence polarization assay | Homo sapiens | 3 | assay format | Scientific Literature |
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