# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4728925 | B | Selectivity ratio of Kd for binding affinity to c-Kit (unknown origin) to binding affinity to Kd for human wild type CSF1R (I564 to S939 residues) | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
2. | ALA4728927 | B | Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by Eu-labeled anti-His antibody addition and measured after 90 mins by FRET based LanthaScreen assay | Homo sapiens | 33 | ALA4725356 | single protein format | Scientific Literature | |
3. | ALA4728928 | B | Binding affinity to human wild type CSF1R (I564 to S939 residues) expressed in bacterial expression system by kinome scan assay | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
4. | ALA4728929 | B | Binding affinity to human wild type FLT3 (V592 to Y969 residues) expressed in bacterial expression system by kinome scan assay | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
5. | ALA4728930 | B | Selectivity ratio of Kd for binding affinity to human wild type FLT3 (V592 to Y969 residues) to binding affinity to Kd for human wild type CSF1R (I564 to S939 residues) | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
6. | ALA4728931 | B | Binding affinity to c-Kit (unknown origin) by kinome scan assay | Homo sapiens | 18 | ALA4725356 | single protein format | Scientific Literature | |
7. | ALA4728932 | B | Selectivity ratio of IC50 for inhibition of human PDGFRbeta phosphorylation in PDGF-DD induced human HEK293-TetR cells to IC50 for Inhibition of CSF1R phosphorylation in M-CSF induced human THP1 cells | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
8. | ALA4728933 | B | Inhibition of human PDGFRbeta phosphorylation in PDGF-DD induced human HEK293-TetR cells incubated for 1 hr followed by PDGF-DD stimulation and measured after 5 mins by HTRF assay | Homo sapiens | 18 | ALA4725356 | tissue-based format | Scientific Literature | |
9. | ALA4728934 | B | Inhibition of CSF1R phosphorylation in M-CSF induced human THP1 cells incubated for 30 mins by ELISA assay | Homo sapiens | 18 | ALA4725356 | tissue-based format | Scientific Literature | |
10. | ALA4728935 | B | Selectivity ratio of Kd for binding affinity to human wild type PDGFRbeta (V582 to Y1009 residues) to binding affinity to Kd for human wild type CSF1R (I564 to S939 residues) | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
11. | ALA4728936 | B | Binding affinity to human wild type PDGFRbeta (V582 to Y1009 residues) expressed in bacterial expression system by kinome scan assay | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
12. | ALA4728937 | B | Selectivity ratio of Kd for binding affinity to human wild type PDGFRalpha (V575 to D1002 residues) to binding affinity to Kd for human wild type CSF1R (I564 to S939 residues) | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
13. | ALA4728938 | B | Binding affinity to human wild type PDGFRalpha (V575 to D1002 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 18 | ALA4725356 | assay format | Scientific Literature | |
14. | ALA4728939 | A | Clearance in CD-1 mouse at 0.3 mg/kg, iv and measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4725356 | organism-based format | Scientific Literature | |
15. | ALA4728940 | B | Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assay | Mus musculus | 27 | ALA4725356 | cell-based format | Scientific Literature | |
16. | ALA4728941 | F | Antiproliferation activity against mouse NSO cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay | Mus musculus | 7 | ALA4725356 | cell-based format | Scientific Literature | |
17. | ALA4728942 | A | Plasma protein binding in CD-1 mouse at 5 uM incubated for 5 hrs by LC-MS analysis | Mus musculus | 2 | ALA4725356 | cell-free format | Scientific Literature | |
18. | ALA4728943 | A | Plasma protein binding in Sprague-Dawley rat at 5 uM incubated for 5 hrs by LC-MS analysis | Rattus norvegicus | 11 | ALA4725356 | cell-free format | Scientific Literature | |
19. | ALA4728944 | A | Plasma protein binding in Beagle dog at 5 uM incubated for 5 hrs by LC-MS analysis | Canis lupus familiaris | 2 | ALA4725356 | cell-free format | Scientific Literature | |
20. | ALA4728945 | A | Plasma protein binding in cynomolgus monkey at 5 uM incubated for 5 hrs by LC-MS analysis | Macaca fascicularis | 2 | ALA4725356 | cell-free format | Scientific Literature |