| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4724674 | B | Displacement of (4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(1,3,5-trimethyl-1H-pyrazol-4-yl)methanone from FNTA in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 2. | ALA4724675 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM pyrophosphate by scintillation proximity assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 3. | ALA4724676 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM phosphate by scintillation proximity assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 4. | ALA4724677 | B | Inhibition of rat recombinant FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM thiosulfate by scintillation proximity assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 5. | ALA4724678 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM ATP by scintillation proximity assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 6. | ALA4724683 | B | Binding affinity to recombinant FTase (unknown origin) assessed as change in melting temperature at 20 uM by TdF assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 7. | ALA4724690 | F | Reactivation of latent HIV-1 infected in human Jurkat 2C4 cells assessed as increase in HIV-1 transcription incubated for 24 hrs by Steady-Glo luciferase reporter gene assay | Human immunodeficiency virus 1 | 4 | organism-based format | Scientific Literature | ||
| 8. | ALA4724691 | F | Potentiation of vorinostat-induced reactivation of latent HIV-1 infected in human Jurkat 2C4 cells assessed as increase in HIV-1 transcription incubated for 24 hrs in presence of vorinostat by Steady-Glo luciferase reporter gene assay | Human immunodeficiency virus 1 | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA4724692 | B | Displacement of (4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(1,3,5-trimethyl-1H-pyrazol-4-yl)methanone from AFG3L2 in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA4724693 | B | Displacement of (4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(1,3,5-trimethyl-1H-pyrazol-4-yl)methanone from NMRAL1 in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4724694 | B | Displacement of (4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(1,3,5-trimethyl-1H-pyrazol-4-yl)methanone from FNTB in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature |
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