| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4667925 | U | Ratio of IC50 for antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay to Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs post-dosing on day 4 by LC/MS analysis | 3 | organism-based format | Scientific Literature | |||
| 2. | ALA4667926 | U | Ratio of IC50 for antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay to Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 30 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs post-dosing on day 4 by LC/MS analysis | 1 | organism-based format | Scientific Literature | |||
| 3. | ALA4667927 | F | Antimalarial activity against Plasmodium chabaudi ASS infected po dosed NIH mouse assessed as inhibition of parasitemia administered oce daily for 4 days starting from 4 hrs post parasite-inoculation and measured at 24 hrs post-last treatment by Peter's 4-day suppressive test | Plasmodium chabaudi | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA4667928 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 30 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs post-dosing on day 4 by LC/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA4667929 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 30 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 6 hrs post-dosing on day 4 by LC/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA4667930 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 30 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 1 hr post-dosing on day 4 by LC/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4667931 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 3 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs post-dosing on day 4 by LC/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4667932 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 3 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 6 hrs post-dosing on day 4 by LC/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4667933 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 3 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 1 hr post-dosing on day 4 by LC/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4667934 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs post-dosing on day 4 by LC/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA4667935 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 6 hrs post-dosing on day 4 by LC/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 12. | ALA4667936 | A | Plasma concentration in NIH mouse infected with Plasmodium chabaudi ASS at 10 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 1 hr post-dosing on day 4 by LC/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA4667937 | F | Antimalarial activity against Plasmodium chabaudi ASS infected in NIH mouse assessed as inhibition of parasitemia at 30 mg/kg, po qd for 4 days starting from 4 hrs post-parasite inoculation and measured at 24 hrs after last-drug treatment by Peter's 4-day suppressive test relative to control | Plasmodium chabaudi | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA4667938 | T | Selectivity index, ratio of non-cytotoxic concentration for human HepG2 cells incubated for 72 hrs by PrestoBlue cell viability reagent based assay to IC50 for CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR green1 dye based fluorescence assay | 1 | assay format | Scientific Literature | |||
| 15. | ALA4667939 | A | Cytotoxicity against human HepG2 cells assessed as cell viability at 50 uM incubated for 72 hrs by PrestoBlue cell viability reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4667940 | A | Apparent volume of distribution in KM mouse at 2 mg/kg, iv administered as cassette dosing measured up to 24 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA4667941 | A | Half life in KM mouse at 2 mg/kg, iv administered as cassette dosing measured up to 24 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA4667942 | A | Inhibition of recombinant human CYP2C19 expressed in baculovirus infected insect cells using s-mephenytoin as substrate incubated for 30 mins in presence of NADPH-regenerating system by fluorescence based assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4667943 | A | Apparent clearance in KM mouse at 2 mg/kg, iv administered as cassette dosing measured up to 24 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4667944 | A | Inhibition of recombinant human CYP2C9 expressed in baculovirus infected insect cells using tolbutamide as substrate incubated for 30 mins in presence of NADPH-regenerating system by fluorescence based assay | Homo sapiens | 3 | cell-based format | Scientific Literature |
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