| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4731795 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in fibronectin protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 2. | ALA4731796 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in collagen type-1 protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 3. | ALA4731797 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in IGFBP-3 protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 4. | ALA4731798 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in CTGF protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 5. | ALA4731799 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in alpha-SMA protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA4731800 | F | Antifibrotic activity in human primary lung fibroblasts assessed as decrease in fibronectin protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA4731801 | F | Antifibrotic activity in human primary lung fibroblasts assessed as decrease in collagen type-1 protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 8. | ALA4731802 | F | Antifibrotic activity in human primary lung fibroblasts assessed as decrease in IGFBP-3 protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 9. | ALA4731803 | F | Antifibrotic activity in human primary lung fibroblasts assessed as decrease in CTGF protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA4731804 | F | Antifibrotic activity in human primary lung fibroblasts assessed as decrease in alpha-SMA protein level at 500 ug/ml measured after 72 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4731805 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in TGFbeta1-induced fibronectin protein level at 500 ug/ml treated at 30 mins to 6 hrs post TGFbeta1 stimulation by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA4731806 | F | Antifibrotic activity in against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in collagen type-1 protein level at 500 ug/ml treated at 30 mins to 6 hrs post TGFbeta1 stimulation by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA4731807 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in IGFBP-3 protein level at 500 ug/ml treated at 30 mins to 6 hrs post TGFbeta1 stimulation by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4731808 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in CTGF protein level at 500 ug/ml treated at 30 mins to 6 hrs post TGFbeta1 stimulation by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA4731809 | F | Antifibrotic activity against TGFbeta1-induced fibrosis in human primary lung fibroblasts assessed as decrease in alpha-SMA protein level at 500 ug/ml treated at 30 mins to 6 hrs post TGFbeta1 stimulation by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 16. | ALA4731810 | F | Antifibrotic activity against bleomycin-induced C57BL/6J mouse lung fibrosis model assessed as reduction in COL1A2 mRNA level at 2%, po via gavage administered as single dose measured within 5 days by qRT-PCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4731811 | F | Antifibrotic activity against bleomycin-induced C57BL/6J mouse lung fibrosis model at 2%, po via gavage administered as single dose measured after 14 days by hematoxylin and eosin staining based microscopic analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4731812 | F | Antifibrotic activity against bleomycin-induced C57BL/6J mouse lung fibrosis model assessed as reduction in hydroxyproline level in lung at 2%, po via gavage administered as single dose measured on 14 days by hydroxyproline assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4731813 | T | Toxicity in bleomycin-induced C57BL/6J mouse lung fibrosis model assessed as body weight loss | Mus musculus | 1 | assay format | Scientific Literature | ||
| 20. | ALA4731814 | T | Toxicity in bleomycin-induced C57BL/6J mouse lung fibrosis model assessed as improvement in mouse survival relative to control | Mus musculus | 1 | assay format | Scientific Literature |
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