| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4680948 | B | Binding affinity to Mycobacterium tuberculosis CysM expressed in Escherichia coli strain BL21 (DE3) incubated for 5 mins by PLP fluorescence-based screening assay | Mycobacterium tuberculosis | 15 | assay format | Scientific Literature | ||
| 2. | ALA4680949 | B | Inhibition of Mycobacterium tuberculosis CysM expressed in Escherichia coli strain BL21 (DE3) assessed as apparent first-order rate constant for the formation of the alpha-aminoacrylate intermediate at 100 uM incubated for 5 mins in presence of OPS by spectrophotometry | Mycobacterium tuberculosis | 19 | assay format | Scientific Literature | ||
| 3. | ALA4680950 | B | Inhibition of Mycobacterium tuberculosis CysM expressed in Escherichia coli strain BL21 (DE3) assessed as reduction in amino-acrylate intermediate formation by measuring residual enzyme activity at 100 uM incubated for 5 mins in presence of OPS by spectrophotometry | Mycobacterium tuberculosis | 10 | assay format | Scientific Literature | ||
| 4. | ALA4680951 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of microbial growth incubated for 5 days by alamar blue assay | Mycobacterium tuberculosis | 10 | organism-based format | Scientific Literature | ||
| 5. | ALA4680952 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv grown under nutrient starvation condition assessed as reduction in nonreplicating cells count incubated for 7 days at 10 ug/ml | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
| 6. | ALA4680953 | F | Bactericidal activity against Mycobacterium tuberculosis H37Rv grown under nutrient starvation condition assessed as reduction in nonreplicating cells count incubated for 7 days at 10 ug/ml in presence of 0.2 mM cysteine | Mycobacterium tuberculosis | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA5262988 | B | Inhibition of hexahistidine-tagged recombinant Mycobacterium tuberculosis CysK2 expressed in Escherichia coli BL21(DE3) assessed as amount of S-sulfocysteine produced using O-acetyl-L-serine as substrate incubated for 30 mins by acid-ninhydrin based spectrophotometric assay | Mycobacterium tuberculosis | 12 | assay format | Scientific Literature | ||
| 8. | ALA5262989 | B | Inhibition of hexahistidine-tagged recombinant Mycobacterium tuberculosis CysK1 expressed in Escherichia coli BL21(DE3) assessed as amount of cysteine produced using O-acetyl-L-serine as substrate incubated for 12 mins by acid-ninhydrin based spectrophotometric assay | Mycobacterium tuberculosis | 12 | assay format | Scientific Literature |
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