# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4725160 | Binding | Inhibition of HPK1 in human PBMC assessed as inhibition of SLP76 phosphorylation by ELISA | Homo sapiens | 6 | ALA4715933 | single protein format | Scientific Literature | |
2. | ALA4725161 | ADME | Apparent permeability of compound in dog MDCKII cells | Canis lupus familiaris | 6 | ALA4715933 | cell-based format | Scientific Literature | |
3. | ALA4725162 | ADME | Half life in Wistar Han rat at 0.1 mg/kg, iv | Rattus norvegicus | 4 | ALA4715933 | organism-based format | Scientific Literature | |
4. | ALA4725166 | ADME | Volume of distribution in Wistar Han rat at 0.1 mg/kg, iv | Rattus norvegicus | 8 | ALA4715933 | organism-based format | Scientific Literature | |
5. | ALA4725167 | Binding | Selectivity ratio of IC50 for CDK2 (unknown origin) by ATP competitive binding assay to IC50 for N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells by HTRF lanthascreen binding assay | Homo sapiens | 25 | ALA4715933 | cell-based format | Scientific Literature | |
6. | ALA4725168 | ADME | Total Plasma clearance in Wistar Han rat at 0.1 mg/kg, iv | Rattus norvegicus | 8 | ALA4715933 | organism-based format | Scientific Literature | |
7. | ALA4725169 | Binding | Selectivity ratio of IC50 for JAK1 (unknown origin) by ATP competitive binding assay to IC50 for N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells by HTRF lanthascreen binding assay | Homo sapiens | 34 | ALA4715933 | cell-based format | Scientific Literature | |
8. | ALA4725170 | Binding | Selectivity ratio of IC50 for JAK2 (unknown origin) by ATP competitive binding assay to IC50 for N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells by HTRF lanthascreen binding assay | Homo sapiens | 34 | ALA4715933 | cell-based format | Scientific Literature | |
9. | ALA4725171 | Binding | Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubated for 1 hr by HTRF lanthascreen binding assay | Homo sapiens | 39 | ALA4715933 | cell-based format | Scientific Literature | |
10. | ALA4725175 | Binding | Inhibition of HPK1 in human PBMC assessed as unbound concentration required for inhibition of SLP76 phosphorylation by ELISA corrected to binding to 10% FBS | Homo sapiens | 6 | ALA4715933 | single protein format | Scientific Literature | |
11. | ALA4725176 | ADME | Unbound clearance in Wistar Han rat at 0.1 mg/kg, iv | Rattus norvegicus | 2 | ALA4715933 | organism-based format | Scientific Literature |