# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4671288 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated cFOS expression by measuring cFOS protein expression at 10 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA4671289 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated cFOS expression by measuring cFOS protein expression at 5 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA4671290 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated cFOS expression by measuring cFOS protein expression at 2 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4671291 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated NFATc1 expression by measuring NFATc1 protein expression at 10 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4671292 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated NFATc1 expression by measuring NFATc1 protein expression at 5 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4671293 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated NFATc1 expression by measuring NFATc1 protein expression at 2 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4671303 | T | Therapeutic index, ratio of LC50 for mouse bone marrow cells to IC50 for Inhibition of human RANKL-induced osteoclastogenesis in RANKL cultured mouse bone marrow cells | 11 | assay format | Scientific Literature | |||
8. | ALA4671305 | A | Cytotoxicity against mouse BMMC assessed as reduction in cell viability measured after 48 hrs by MTT assay | Mus musculus | 46 | cell-based format | Scientific Literature | ||
9. | ALA4671306 | B | Inhibition of human RANKL-induced osteoclastogenesis in RANKL cultured mouse bone marrow cells assessed as reduction in RANKL/M-CSF-induced TRAP activity preincubated with RANKL for 1 hr followed by cell addition and subsequent media replenishment every 48 hrs for 4 days | Homo sapiens | 11 | cell-based format | Scientific Literature |